补肾活血法干预系统性红斑狼疮患者使用免疫抑制剂引起卵巢早衰的临床研究  

Clinical Research of Applying Bushen Huoxue Method in the Intervention of Premature Ovarian Failure Caused by Immunosuppressions in Systemic Lupus Erythmatosis

作　　者：刘潇潇[1] 练颖 

机构地区：[1]成都市第一人民医院血液风湿科,四川成都620200

出　　处：《四川中医》2016年第6期102-104,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察补肾活血法对系统性红斑狼疮(Systemic Lupus Erythematosis,SLE)女性患者使用免疫抑制剂引起卵巢早衰(premature ovarian failure,POF)后的临床疗效。方法:选取63例因使用环磷酰胺(Cyclophosphamide,CYC)或者雷公藤多苷(Tripterygium wilfordii glycoside,TWG)导致卵巢早衰的女性患者,记录使用补肾活血法(生地30g,知母15g,女贞子15g,肉苁蓉15g,巴戟天15g,赤芍15g,郁金15g,丹皮15g,益母草15g,炙甘草6g)半年后患者临床症状变化、患者体内E2、FSH、子宫内膜厚度变化,使用t检验、方差分析、卡方检验等统计学方法对相关数据进行统计。结果:经中药治疗的患者卵巢早衰的症状得到改善,血清中E2有所上升,FSH下降,子宫内膜厚度有所增加,窦卵泡数增加。结论:补肾活血法为治疗SLE患者使用免疫抑制剂后所致卵巢早衰的有效方法。Objective： To study the effect of Bushen Huoxue Recipe on premature ovarian failure（ POF） caused by immunosuppressions in systemic lupus erythmatosis. Methods： 63 SLE cases of women with premature ovarian failure who was treated with cyclophosphamide（ CYC） or the tripterygium wilfordii glycoside（ TWG） was chosen. Recording the changes of the clinic symptoms and the laboratory indicators such as E2,FSH,endometrial thickness during 6 months using Bushen Huoxue Recipe.Using statistical methods（ t test,analysis of variance,chi-square test,etc.） for statistical data. Results： The symptoms of premature ovarian failure was improved the patients with traditional Chinese medicine treatment; serum E2 increased,FSH decreased,endometrial thickness increased,and the number of antral follicles increased. Conclusion： Bushen Huoxue Recipe is an effective method of SLE patients with premature ovarian failure induced by immunosuppressions.

关 键 词：系统性红斑狼疮 免疫抑制剂 卵巢早衰 补肾活血法 

分 类 号：R243.2[医药卫生—中医临床基础]