激素替代疗法联合柴胡加龙骨牡蛎汤对妇女绝经后期失眠抑郁症状及激素水平的影响研究  

Influence Study of Combining Hormone Replacement Therapy and Chaihu plus Longgu Muli Decoction on Insomnia Depression Symptoms and Hormone Levels in Postmenopausal Women

作　　者：全燕[1] 曾晓莉[1] 

机构地区：[1]十堰市妇幼保健院妇女保健科,湖北十堰442000

出　　处：《四川中医》2016年第6期123-125,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察激素替代疗法(HRT)联合柴胡加龙骨牡蛎汤对绝经后期妇女失眠、抑郁症状及激素水平的影响。方法:选取134例绝经后期的围绝经期综合症患者为研究对象,采用随机数字表法将其分成研究组(A组,n=67)和对照组(B组,n=67)两组。B组予以HRT疗法,A组予以HRT联合柴胡加龙骨牡蛎汤疗法。比对两组患者治疗前及治疗3个月后抑郁评分、睡眠质量评分及激素水平变化差异。结果:1治疗3个月后,两组患者HAMD评分与PSQI评分均较治疗前显著降低,其中A组降幅大于B组(P<0.05);2治疗后,两组患者LH、FSH等激素水平均较治疗前显著降低,且E2水平较治疗前显著提高(P<0.05);其中A组各指标变化幅度均大于B组(P<0.05)。结论:对绝经后期妇女予以HRT联合柴胡加龙骨牡蛎汤疗法,能有效改善其抑郁情绪、提高激素水平,利于缓解失眠症状、提高预后质量及生活质量,值得临床推广。Objective： To investigate the effect of hormone replacement therapy（ HRT） combined with Chaihu plus Longgu Muli Decoction on insomnia,depression and hormone levels in postmenopausal women. Methods： 134 postmenopausal patients with peri-menopausal syndromes were taken as the research objects. According to the random number table method,the patients were divided into research group（ group A,n = 67） and controlled group（ group B,n = 67）. Group B was treated with HRT while group A was treated with HRT combined with Chaihu plus Longgu Muli Decoction. Before the treatment and 3 months of treatment later,the depression scores,sleep quality scores and changes of hormone levels in the two groups were compared. Results： ①3 months of treatment later,HAMD scores and PSQI scores of the two groups were significantly lower than those before the treatment and the decrease in group A was greater than that in group B（ P〈0. 05）. ②After the treatment,the levels of hormones such as LH and FSH in the two group were significantly lower than those before the treatment while E2 levels were significantly higher than those before the treatment（ P〈0. 05）. The changes of the inexes in group A were greater than those in group B（ P〈0. 05）. Conclusion： To adopt HRT combined with Chaihu plus Longgu Muli Decoction in the treatment of postmenopausal women can effectively improve their depressive mood and improve the hormone levels. It is conductive to remit the insomnia symptom and improving the prognosis quality and quality of life. It is worthy of clinical promotion.

关 键 词：激素替代疗法 柴胡加龙骨牡蛎汤 绝经后期 失眠 抑郁 激素水平 

分 类 号：R711.75[医药卫生—妇产科学]