水相中苯甲酰腙类化合物的绿色合成  

GREEN SYNTHESIS OF BENZOYL HYDRAZONES IN WATER

作　　者：王慧彦[1,2] 孟瑶[1] 季媛媛[1] 杨帆[1] 尹福军[2] 周亚[1] 

机构地区：[1]淮海工学院化学工程学院,连云港222005 [2]江苏省海洋资源开发研究院,淮海工学院,连云港222005

出　　处：《离子交换与吸附》2016年第3期253-261,共9页Ion Exchange and Adsorption

基　　金：江苏省海洋资源开发研究院开放课题基金项目(批准号JSIMR201304);江苏省高等学校大学生创新创业训练计划省级指导项目(批准号201411641083X)

摘　　要：酰腙类化合物含有-CO-NH-N=CH-特殊结构，通常是由醛或酮与酰肼通过缩合反应制备，因其药理活性而引起人们的广泛注意。本文在强酸性阳离子交换树脂NKC-9催化条件下，采用醛／酮与苯甲酰肼进行反应，合成了11个苯甲酰腙类化合物。反应过程通过TLC跟踪，产物以FT-IR、H-NMR等手段进行表征。催化剂经过简单处理可重复使用。Hydrazones with functional groups of-CO-NH-N=CH- were usually prepared via condensation of aldehydes or ketones with hydrazines. They were well known for their pharmacological activities. In this article, 11 kinds of benzoyl hydrazones were synthesized by reaction of aldehydes/ketones and benzoyl hydrazine with strong acid resin of NKC-9 as catalyst in water. The process was traced by TLC and the products were characterized by melting point, FT-IR and ^1H-NMR. The catalyst showed higher catalytic activity and reusability.

关 键 词：苯甲酰腙 固体酸 强酸性阳离子交换树脂 催化 

分 类 号：TL284[核科学技术—核燃料循环与材料] O643.32[理学—物理化学]