MicroRNA在中耳胆脂瘤发病机制研究进展  

Research progress of MicroRNA in the pathogenesis of cholesteatoma

作　　者：巴合提江.托克吉各特 阿依恒.曲库尔汗[1] 

机构地区：[1]新疆医科大学第一附属医院耳鼻喉科,新疆830054

出　　处：《中华耳科学杂志》2016年第2期304-307,共4页Chinese Journal of Otology

基　　金：新疆维吾尔自治区自然科学基金项目(2013211A098)~~

摘　　要：微小RNA(Micro RNA)是生物体内小分子RNA,参与细胞内转录调节、能量代谢、生长发育、增殖等多生物学功能,是人体内细胞基因调控中的重要调节分子。近年来大量胆脂瘤发生、发展中的分子生物学研究取得了新进展,其中mi RNA在胆脂瘤的研究中开辟了新的研究领域。近来大量报道认为mi R-21可能与胆脂瘤的发病机制有关,并且在胆脂瘤生长调节和扩散中具有潜在作用。本文针对mi R-21在细胞信号通路间及相互作用对于中耳胆脂瘤发生、发展中的作用机制进行了综述。Micro RNA which has variety of biological functions in cells is a small RNA molecule in the organism, participates in transcriptional regulation, energy metabolism, growth, reproduction and so on. Micro RNAs are important molecules in cell gene regulation in body, and exercise a variety of biological function. In recent years, a large number of molecular biology researches in pathogenesis of cholesteatoma of middle ear, have made a new progress of which mi RNAs study and opened a new field.Mi R-21 may be related with the occurrence and development of cholesteatoma of middle ear, and has played a potential role in cholesteatoma of middle ear in growing and diffusing. This paper reviewed the researching progress of the mi R-21 and cellular signaling pathways and their interaction in occurrence mechanism and development of cholesteatoma of middle ear.

关 键 词：中耳胆脂瘤 微小RNAS 发病机制 

分 类 号：R764[医药卫生—耳鼻咽喉科]