中药复方抗肝纤维化药理作用研究进展  

Review of the pharmacology of traditional Chinese medicine compounds in the treatment of liver fibrosis

作　　者：李光全[1,2] 黄奕雪 尹萍[2] 桑秀秀 贺兰芝 王家葵[1] 柏兆方[2] 

机构地区：[1]成都中医药大学药学院,中药材标准化教育部重点实验室,四川省中药资源系统研究与开发利用重点实验室省部共建国家重点实验室培育基地,四川成都611137 [2]中国人民解放军第三〇二医院,北京100039

出　　处：《中药与临床》2016年第2期95-98,共4页Pharmacy and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金资助项目(81503350)

摘　　要：肝纤维化是广泛存在于慢性肝病中以细胞外基质过量沉积为特征的损伤修复反应,在全球具有较高发病率和病死率。在缺乏有效抗肝纤维化西药的同时,许多行之有效的中药复方逐渐得到了认可。本文总结了近年来国内外研究的一些典型中药复方,分别从活血化瘀、补益、清热祛湿和疏肝健脾等4个方面进行综述。旨在方便研究者系统地了解抗肝纤维化中药复方的研究进展,为临床组方以及抗肝纤维化药物的进一步研究提供一定参考。Liver fibrosis is an excessive wound-healing response that is characterized by an increased deposition and altered composition of extracellular matrix in the liver. It is widely exist in chronic liver disease and results in very high morbidity and mortality in the world. However, specific anti-fibrotic drugs that are approved for the treatment of liver fibrosis remain limited in the western countries. In contrast to the lack of anti-fibrotic drugs in western medicine, there is accumulating evidence supporting the beneficial effects of traditional Chinese medicine compounds for the treatment of liver fibrosis. In this paper, we reviews the research advances of Chinese medicine compounds for the treatment of liver fibrosis from 4 aspects as blood-activating and stasisdissolving, restorative, expelling heat-dehygrosis, and relieving liver and reinforcing spleen. In this review, we aimed to provide some value in the study of prescription design in clinic, as well as the experimental study of anti-fibrotic medicine.

关 键 词：中药复方 肝纤维化 药效 机制 综述 

分 类 号：R284[医药卫生—中药学]