黄精赞育胶囊对弱精子症患者精子DNA完整性的影响  

Impacts of Huangjingzanyu capsule on sperm DNA integrity of patients with asthenospermia

作　　者：刘炜[1] 付睿[1] 赵晨[1] 黄燕平[1] 平萍[1] 陈斌[1] 黄翼然[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科,上海200127

出　　处：《中国男科学杂志》2016年第4期34-37,共4页Chinese Journal of Andrology

摘　　要：目的探讨黄精赞育胶囊对弱精子症患者精子DNA完整性的影响。方法选择弱精子症患者58例,常规服用黄精赞育胶囊3个月,应用流式细胞术(Flow Cytometry,FCM)和计算机辅助精液分析(computerassisted semen analysis,CASA)技术,分别检测并对照分析治疗前后精液参数和精子DNA完整性指标(DFI)变化。结果治疗前58例弱精子症患者精子密度、a级精子百分率、(a+b级)精子百分率、活动率与DFI呈显著负相关(r=-0.38,-0.56,-0.52,-0.64,P均<0.05),畸形率与DFI呈显著正相关(r=0.42,P<0.05)。治疗3个月后,患者精子密度、a级精子百分率、(a+b级)精子百分率、活动率、畸形率与治疗前相比差异有统计学意义;精液量、pH值、液化时间与治疗前相比差异无统计学意义(P<0.05):DFI正常组的DFI值与治疗前相比差异无统计学意义,DFI异常组的DFI值与治疗前相比差异有统计学意义(P<0.05)。结论黄精赞育胶囊可显著提高弱精子症患者精子密度、精子总数、活力、活动率,并可显著降低精子的畸形率,对于DFI异常的弱精子患者,使用黄精赞育胶囊可以明显改善精子DNA完整性。Objective To explore the Impacts of Huangjingzanyu capsule on sperm DNA integrity of patients with asthenospermia. Methods Flow Cytometry（FCM） and computer-assisted semen analysis（CASA） were used to detect and analyze the changes of semen parameters and sperm DNA integrity index（DFI） before and after the therapy, in which 58 patients with asthenospermia took Huangjingzanyu capsule for three months. Results The sperm density, sperm motility a, a＋b and sperm viability of the 58 patients negatively correlated with DFI（r=-0.38,-0.56,-0.52,-0.64, P〈0.05） before the therapy while the teratospermia rate positively correlated with DFI （r=0.42, P〈0.05）. After three months, there were signifi-cant differences in above parameters （P〈0.01） and no significant differences were found in volume（P=0.301）, pH（P=0.098） or liquate time（P=0.796） of semen before and after the therapy. In addition, the change of DFI had no difference（P=0.326） in the group with normal DFI before the therapy, whereas the change had significant difference（P=0.000） in the group with ab-normal DFI before the therapy. Conclusion For the patients with asthenospermia, Huangjingzanyu capsule can significantly improve the density, number, motility and viability of their sperm and reduce the teratospermia rate, and it can also improve the sperm DNA integrity for those who have abnormal DFI.

关 键 词：黄精赞育胶囊 弱精子症 精子DNA完整性 

分 类 号：R698.2[医药卫生—泌尿科学]