CABYR生物学功能及其应用  

Biological Function and Application of CABYR

作　　者：钱尊磊 李敏[2] 肖倩倩[3] 苗翠英[1] 李同[1] 庄柯彧 郭子嘉[4] 

机构地区：[1]中国人民公安大学刑事科学技术学院,北京100038 [2]长治医学院附属和平医院,长治046000 [3]北京大学公共卫生学院,北京100083 [4]北京育才学校,北京100050

出　　处：《基因组学与应用生物学》2016年第6期1335-1341,共7页Genomics and Applied Biology

基　　金：中国人民公安大学基本科研业务费项目(2015JKF01236)资助

摘　　要：钙离子结合酪氨酸磷酸化调节基因CABYR是一种与钙离子信号通路相关的基因,该基因具有两个编码区,编码产生一种高度多态性蛋白。CABYR蛋白定位于人精子鞭毛纤维鞘主段,与精子的能育力获得和鞭毛纤维鞘形成紧密相关。CABYR在睾丸组织和多种肿瘤组织中高表达,正常组织中不表达或低表达,并能引起特异性体液免疫反应,被鉴定为一种与肺癌相关的的CT抗原。CABYR的表达水平对肿瘤细胞的增殖、迁移和多种抗肿瘤药物敏感性起重要作用。CABYR在肿瘤免疫治疗、抗肿瘤药物筛选以及法医物证中精液斑的检验鉴定具有潜在应用价值。Calcium binding tyrosine phosphorylation regulated（CABYR） gene is associated with calcium signaling pathways,which gene contains two coding regions,encoding a highly polymorphic protein.CABYR proteins localize to the principal piece of the human sperm flagellum in association with the fibrous sheath,which is closely related with capacitation of sperm as well as the formation of fibrous sheath of spermatozoon.CABYR protein with protein tyrosine kinases activity,high expressed in testicular tissue and a variety of tumor tissues,but no or low expression in normal tissues,which can induce specific humoral immune response.Thus,CABYR protein has been identified as a cancer/testis antigen in lung cancer which plays an important role in the proliferation,metastasis of tumor and the anti-tumor drug sensitivity.CABYR has the potential application value in tumor immunotherapy,anti-tumor drug screening and semen spot inspection in forensic science.

关 键 词：CABYR CT抗原 肿瘤 抗肿瘤药物 

分 类 号：D919[医药卫生—法医学] R730.2[政治法律—法学]