循环microRNA在冠心病及其中医证候诊断中的作用  

Role of Circulating MicroRNA in the Diagnosis of Coronary Heart Disease and TCM Syndrome

作　　者：彭岭[1] 郭宗耀 李杰[2] 胡志希[2] 简维雄[2] 张月娟[2] 

机构地区：[1]湖南中医药大学研究生教育学院,湖南长沙410208 [2]湖南中医药大学中医诊断研究所,湖南长沙410208

出　　处：《湖南中医药大学学报》2016年第5期85-89,共5页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(81302883;81202647);湖南省科技厅计划项目(2013RS4038);中医内科学省部共建教育部重点实验室开放基金(ZYNK201407);湖南省中医药科研计划项目(201427)

摘　　要：micro RNA是一类长度约为22个核苷酸的内源性非编码RNA,并能以特定的方式与靶基因结合,从而抑制靶基因的翻译或使其降解。micro RNA只有在受到致病因素(如环境因素)的影响以及病理状态下,其表达量才会发生改变,因此micro RNA具有成为各种疾病的诊断生物标志物的可能。目前有大量研究表明micro RNA参与冠心病发生发展,但其作用机制尚未完全阐明,本文从micro RNA的特性、micro RNA与冠心病、micro RNA与中医证候等方面对近年来国内外的研究做一综述。MicroRNA is a kind of endogenous non encoding RNA with a length of about 22 nucleotides, and can be combined with target genes in a specific way, thereby inhibiting the translation of target genes and degrading them. The expression level of microRNA will change only in the affected and pathological conditions, such as environmental factors. Therefore, microRNA has become the biomarkers of diagnosis of a variety of diseases. At present, a large number of studies have indicated that microRNA is involved in the development of coronary heart disease, but its mechanism is not yet fully clarified. This article reviews the characteristics of microRNA, role of circulating microRNA in the diagnosis of coronary heart disease and TCM Syndrome.

关 键 词：MICRORNA 冠心病 中医证候 生物标志物 

分 类 号：R259[医药卫生—中西医结合]