萸姜药效组分对小鼠急性心肌缺血的影响研究  

Research on the effect of composition of Yu-Jiang on AMI mice

作　　者：覃海龙[1] 宋胜武[1] 云雪林[1] 

机构地区：[1]贵阳中医学院药学院,贵州贵阳550002

出　　处：《贵阳学院学报（自然科学版）》2016年第2期27-31,共5页Journal of Guiyang University：Natural Sciences

基　　金：贵州省教育厅科研课题重点项目:"萸姜药效组分方剂配伍研究"(项目编号:黔教科第2010048号)

摘　　要：目的:探寻萸姜药效组分对小鼠急性心肌缺血的影响。方法:以腹腔注射ISO制备小鼠常压缺氧模型和急性心肌缺血模型,对照丹参片组观察不同浓度萸姜药效组分对小鼠耐常压缺氧与急性心肌缺血的作用;以腹腔注射Pit制备小鼠急性心肌缺血模型,对照硝苯地平片组观察不同浓度萸姜药效组分对小鼠急性心肌缺血的作用。结果:小鼠耐常压缺氧和ISO致小鼠急性心肌缺血实验结果显示,复方丹参片组能明显延长小鼠存活时间(P<0.05)及有效抑制小鼠心电图S-T段抬高(P<0.05),萸姜药效组分的高、中、低剂量对小鼠存活时间无显著影响(P>0.05),对小鼠心电图S-T段无显著影响(P>0.05)。Pit致小鼠急性心肌缺血实验结果显示,硝苯地平组与萸姜组分高剂量组均能有效抑制小鼠心电图S-T段抬高(P<0.05),萸姜组分低剂量组对小鼠心电图S-T段无显著影响(P>0.05)。结论:萸姜药效组分对Pit致小鼠急性心肌缺血具有明显的改善作用。Objective： To seek the effect of composition of Yu-Jiang on AMI mice. Methods： By intraperitoneal injection of ISO to mice model of normobaric hypoxia and AMI. The effect of mice of normobaric hypoxia and AMI verified the different concentration of the components of Yu-Jiang comparison with Salvia Tablets. By intraperitoneal injection of Pit to mice model of AMI,comparing with Nifedipine Tablets research the different concentration of the components of Yu-Jiang on the mice model of AMI. Results： The results of the two tests showed that compound danshen tablets group can obviously prolong the survival time of mice（ P〈0. 05）,significantly inhibit the rise of ECG S T segment（ P〈0. 05）,Yu-Jiang groups had no obvious effect on the survival time of mice（ P〉0. 05）,and they were not significant impact for ECG（ P〉0. 05）. The test of AMI mice caused by Pit showed that both the group of Nifedipine Tablets group and high dose group of Yu-Jiang can significantly inhibit the rise of ECG S T segment（ P〈0. 05）,low dose group of Yu-Jiang was not significant impact for ECG（ P〉0. 05）. Conclusion： The composition of Yu-Jiang have obvious positive effects on the mice model of AMI caused by Pit.

关 键 词：干姜挥发油 吴茱萸挥发油 组分 急性心肌缺血 PIT 

分 类 号：R285.5[医药卫生—中药学]