非典型抗精神病药物所致体质量增加与黑皮质素4受体的相关性研究  

Association between weight gain induced by atypical antipsychotic and the polymorphisms of MC4R gene rs12970134

作　　者：张璇[1] 曾环思[1] 郭媛媛[1] 杨叶雅[1] 王知力[1] 

机构地区：[1]深圳市精神卫生中心药学部,广东省深圳518020

出　　处：《中国基层医药》2016年第13期1963-1966,I0002,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省深圳市科技研发资金项目（JCYJ20150402093137766）

摘　　要：目的：探讨非典型抗精神病药物所致患者体质量增加与黑皮质素4受体基因（MC4 R ） rs12970134多态性的关系。方法研究组为62例服用抗精神病药物1年内体质量增加≥7％的精神分裂症患者，对照组为62例与研究组服用相同的抗精神病药物、1年内体质量增加＜7％的患者。采用聚合酶链反应及基因测序技术，测定研究对象 MC4R 基因 rs12970134多态性。结果两组 MC4R 基因 rs12970134位点基因型及等位基因频率的差异均无统计学意义（χ2＝0．648，P ＝0．723；χ2＝0．679，P ＝0．410）。但 GG 基因型的患者经抗精神病药物治疗后体质量增加的程度明显小于携带 GA ／AA 基因型的患者[（22．18±0．33）kg／m2比（23．53±0．58）kg／m2]，差异有统计学意义（t ＝－2．167，P ＝0．032）。结论MC4R 基因 rs12970134多态性可能对抗精神病药物治疗后患者体质量增加的程度有影响。Objective To determine the association between weight gain induced by atypical antipsychotic and the polymorphisms of MC4R gene rs12970134.Methods 62 patients who had weight gain more than 7% of their pre -drug body weight were selected as study group,and 62 patients who had weight gain less than 7% of their pre -drug body weight were selected as control group.The polymorphism of MC4R gene rs12970134 was analyzed by using polymerase chain reaction and directly sequencing technology.Results There were no significant differences in the frequency of MC4R gene rs12970134 genotypes and alleles between the two groups（χ2 =0.648,P =0.723;χ2 =0.679,P =0.410）.While after the treatment with atypical antipsychotic,the weight gain degree in patients with GG genotypes was less than patients with GA /AA genotypes[（22.18 ±0.33）kg/m2 vs.（23.53 ±0.58）kg/m2 ]（t =-2.167,P =0.032）.Conclusion The polymorphisms of MC4R gene rs12970134 maybe affect the weight gain degree in patients after treatment with antipsychotic.

关 键 词：基因 黑皮质素 4 受体 非典型抗精神病药物 体质量 基因 多态性 

分 类 号：R969[医药卫生—药理学]