红花籽粕提取物对糖尿病大鼠的降脂作用  

Effect of Safflower Meal Extract on Decreasing Serum Lipid Levels in Rats with Diabetes Mellitus

作　　者：田华[1] 信学雷[1] 麦提喀斯木.尼扎木丁 刘丛丛[1] 阿吉艾克拜尔.艾萨 

机构地区：[1]中国科学院新疆理化技术研究所,乌鲁木齐830011 [2]新疆医科大学

出　　处：《解放军预防医学杂志》2016年第3期351-353,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：国家自然科学基金新疆联合基金(No.U1203203);国家科技支撑计划项目(No.2011DA105B05)

摘　　要：目的研究红花籽粕提取物对糖尿病大鼠血脂水平的影响,为临床治疗Ⅱ型糖尿病提供依据。方法采用SD大鼠建立糖尿病大鼠模型,用红花籽粕提取物高、中、低3个剂量灌胃,连续4周,采集大鼠血清,用全自动生化仪测量总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量,并计算动脉粥样硬化指数。结果与模型组比较,各给药组可以显著降低TC、TG、LDL-C的含量,显著升高HDL-C含量;各给药组的动脉粥样硬化指数均降低,且有显著性差异。结论红花籽粕提取物具有显著降低糖尿病大鼠血脂的作用。Objective To observe the effect of safflower meal extract on serum Lipid levels in rats with diabetes and provide experimental data for clinical therapy of ]]diabetic mellitus. Methods The SD rats were fed on a diet enriched in fat and glucose to induce insulin resistant. 30 mg/kg streptozotocin （STZ） was injected intraperitoneally to induce hyperglycemia to establish T2DM. The experimental rats were divided into normal control group,model group,safflower meal extract （40mg/kg,80mg/kg,160mg/kg） exposure groups and Xuezhikang treat group（lg/kg） .by intragastric administration. After 4 weeks,the rats were sacrificed. We de- tected serum lipids （TC, TG, HDL-C, LDL-C） and calculated atherosclerosis index. Results The Safflower meal extract reduced the levels of TC,TG, LDL-C and atherosclerosis index of rats with diabetes mellitus. The content of HDL-C in exposure groups were significantly higher than that of the model group, Conclusion The safflower meal extract had apparente effects on decreasing serum lipid levels of rats with diabetes mellitus.

关 键 词：红花籽粕提取物 糖尿病 血脂 

分 类 号：R587.1[医药卫生—内分泌] R247.1[医药卫生—内科学]