西格列汀联合二甲双胍对血糖升高代谢综合征的干预作用  

Effects of Sitagliptin Combined with Metformin on Hyperglycemia Metabolic Syndrome

作　　者：张坤[1] 任巧华[1] 吴韬[1] 杜俊文[1] 

机构地区：[1]石家庄市第一医院内分泌科,石家庄050000

出　　处：《解放军预防医学杂志》2016年第3期364-366,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：2013年石家庄市科学技术研究与发展指导计划(No.131462423)

摘　　要：目的探讨西格列汀联合二甲双胍治疗血糖升高的代谢综合征的临床疗效,为血糖升高的代谢综合征患者的治疗提供临床依据。方法选取2013年1月至2014年6月我院收治的血糖升高的代谢综合征患者75例,按照随机抽样方法分为观察组和对照组,对照组给予二甲双胍治疗,观察组给予西格列汀联合二甲双胍治疗,2组均给予同样的饮食和运动方案,疗程均为12周。检测2组患者的腰围(WC)、体质指数(BMI)、血糖、血脂、空腹胰岛素、血清脂联素等生化指标,计算稳态模型胰岛素抵抗指数(HOMA-IR)和总体胰岛素敏感指数(WBISI)并进行对比。结果治疗后,观察组和对照组患者的WC、BMI、收缩压(SBP)、舒张压(DBP)、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、空腹血糖(FPG)、餐后2 h血糖(2h PG)、空腹胰岛素(FINS)、HOMA-IR、WBISI和血清脂联素均较治疗前明显改善,观察组改善效果优于对照组(P<0.05)。结论西格列汀联合二甲双胍治疗血糖升高的代谢综合征临床疗效更显著。Objective To investigate the curative effect of sitagliptin combined with metformin in the treatment of hyperglycemia metabolic syndrome. Methods A total of 75 patients with hyperglycemia metabolic syndrome admitted in our hospital from Jan 2013 to Jun 2014 were selected and divided randomly into the observation group （n = 37） and control group （n = 38 ）. Same diet and exercise plan were given to the two groups. Then the observation group was given sitagliptin and metformin treatment, while the control group was given metformin treatment for 12 weeks. The waist circumference （WC）, body mass index （BMI）, blood glucose, blood lipid, fasting insulin, serum adiponectin and other biochemical indicators were detected and compared. The steady-state model of insulin resistance index （HOMA-IR） and whole body insulin sensitivity index （WBISI） were calculated. Results After treatment, there were statistically differences （ P〈0.05 ） between the two groups in WC, BMI, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, triglycerides （TG）, cholesterol （TC）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, fasting plasma glucose （FPG）, 2 h postprandial blood glucose （2 h PG）, fasting insulin （FINS）, HOMA-IR, WBISI and serum adiponectin; The above indexes of the observation group and control group were both obviously improved, and the improved effect of observation group was significantly better than that of the control group （P〈0.05）. Conclusion The sitagliptin combined with mefformin has better curative effect in treatment of hyperglycemia metabolic syndrome.

关 键 词：代谢综合征 西格列汀 二甲双胍 血清脂联素 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]