老年2型糖尿病共患抑郁症的机制及治疗现状  

Mechanism and treatment of comorbid depression in elderly patients with type 2 diabetes mellitus

作　　者：张军[1] 韩旸[1] 王凯亮[1] 张雪冰[1] 李洪梅[1] 

机构地区：[1]煤炭总医院内分泌科

出　　处：《中华老年多器官疾病杂志》2016年第6期422-425,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：流行病学调查资料证实2型糖尿病（T2DM）易共患抑郁症。目前研究认为下丘脑一垂体一。肾上腺（HPA）轴功能过度活跃，炎症介质、神经递质及基因变化等因素可能在两者的共患机制中起重要作用。不同类型抗抑郁药物对T2DM患者的血糖影响不同，选择合适的抗抑郁药物或精神、心理干预措施，可能有益于T2DM共患抑郁症患者的综合管理。抑郁症的诊治专科性质较强，应由精神专科医师进行评估，提供系统治疗方案。Epidemiological surveys confirmed that type 2 diabetes mellitus （T2DM） and depression are often comorbid. Evidence from animal and clinical researches showed that hyperaetivation of the hypothalamic-pituitary-adrenal （HPA） axis, and changes in genes, neurotransmitters and inflammatory mediators may play the important roles in the comorbidity of these two chronic illnesses. Different anti-depressants have various influences on the control of blood glucose, so appropriate antidepressants or psyehosoeial and psychological interventions may contribute to the comprehensive management of T2DM patients with eomorbid depression. Since diagnosis and treatment of depression require professional expertise, it is psychopathy specialists who ought to evaluate and provide systemic treatment program.

关 键 词：糖尿病 抑郁症 共患疾病 

分 类 号：R587.1[医药卫生—内分泌] R592[医药卫生—内科学]