乙型肝炎病毒前S/S基因突变及表位变异与HCC发病关系的研究进展  

Association Between Pre-S/S Mutations and Epitope Mutations of Hepatitis B Virus and HCC

作　　者：李丽娟[1] 许可[1] 高艺洋[1] 李玮珏 张招龙 曾文铤[2] 

机构地区：[1]广州医科大学,广东广州510000 [2]广州医科大学附属第一医院,广东广州510120

出　　处：《现代医院》2016年第6期788-791,共4页Modern Hospitals

基　　金：广东省科技计划项目(编号:2013B022000101)

摘　　要：乙型肝炎病毒(HBV)慢性感染是肝细胞癌(HCC)发病重要的危险因素。目前关于HBV前S/S基因突变与HCC发病关系的研究认为,前S/S突变尤其是前S缺失突变与HCC发病密切相关。前S缺失突变可通过改变细胞表位与HLA分子的结合能力,导致T/B细胞表位免疫原性改变,从而逃逸宿主的免疫监视,产生免疫逃避或免疫耐受,由此增加发展为HCC的风险。笔者对前S/S基因突变和表位变异与HCC发病的关系作一综述。Chronic hepatitis B virus （HBV） infection has been documented as a major risk factor to the pathogenesis of hepatoeellular carcinoma （ HCC ）. Currently studies about the correlation between the mutations in pre - S/S regions of HBV and HCC indicated that pre -S/S gene mutations, especially the pre -S deletion mutations were independent risk factors of HCC. Pre - S deletion mutations often induce the loss of T - and B - cell epitopes, which may evade the host immune surveillance via reduction in affinity between epitopes and HLA molecules. This may influence the progression of liver diseases and the occurrence of HCC.

关 键 词：乙型肝炎病毒 前S/S基因 表位变异 肝细胞癌 

分 类 号：R373.21[医药卫生—病原生物学]