成纤维细胞生长因子7对肝硬化大鼠肝切除术后肝脏再生的作用研究  

The Effect of FGF7 on Liver Regeneration with Liver Cirrhosis after Hepatectomy in Ratsmodel

作　　者：朱柱[1] 张韩静 罗礼炳 李果[1] 罗加兴[1] 

机构地区：[1]南华大学附属第一医院肝胆外科,衡阳421001

出　　处：《数理医药学杂志》2016年第7期1004-1006,共3页Journal of Mathematical Medicine

基　　金：湖南省卫生计生委科研课题(C2016082)

摘　　要：目的:明确成纤维细胞生长因子(Fibroblast Growth Factor7,FGF7)在肝硬化肝大部切除术后肝脏再生的作用。方法:建立四氯化碳诱导的肝硬化大鼠模型,在此基础上行70%肝切除术,门静脉注射FGF7,检测术后残余肝重量及增殖指数。结果:大鼠四氯化碳诱导12周后,术中见肝脏表面呈小结节样改变,镜下见正常肝小叶结构破坏,被假小叶取代。对照组与实验组残余肝第3、5、7d重量(g)分别为(3.2±0.2vs.3.6±0.3)、(3.4±0.3vs.5.8±0.5)、(4.0±0.4vs.6.9±0.6),其中两组第5、7d差异具有统计学意义(P<0.05)。对照组与实验组残余肝第3、5、7天增殖指数(%)分别为8.2±1.3vs.12.4±1.6、10.4±1.5vs.21.3±2.1、15.8±1.4vs.29.9±2.7,其中两组第5、7d差异具有统计学意义(P<0.05)。结论:FGF7促进肝硬化肝切除术后肝脏再生,为肝硬化患者行肝切除术提供了理论支持。Objective：To clarify the role of Fibroblast Growth Factor7（FGF7）in liver regeneration after hepatectomy in cirrhotic patients with liver cirrhosis.Methods：Establish the rat model of liver cirrhosis in-duced by carbon tetrachloride,and then 70% liver resection was performed on the basis of liver resection. The liver weight and proliferation index were detected after the portal vein inj ection of FGF7 .Results：The liver surface was small nodule like changes in the liver,and the structure of the normal liver was destroyed under the microscope 1 2 weeks later.The control group and experimental group residual liver third,5 ,7 days of weight （g）were （3.2±0.2 vs.3.6±0.3）,（3.4±0.3 vs.5.8±0.5）,（4.0±0.4 vs.6.9±0.6）,of which two groups of fifth,7 days of the difference was statistically significant （P〈0.05）.Control group and exper-imental group of residual liver the 3,5,7 days proliferation index （%）were （8.2±1.3 vs.12.4±1.6）and （10.4±1.5 vs.21.3±2.1）,（15.8±1.4 vs.29.9±2.7）,in which two groups of 5 and 7 days difference has sta-tistical significance （P 〈 0.05）.Conclusion：FGF7 promotes liver regeneration after hepatectomy for liver cirrhosis,which provides theoretical support for liver resection in patients with cirrhosis.

关 键 词：肝硬化 肝切除术 成纤维细胞生长因子 肝脏再生 大鼠 

分 类 号：R657.31[医药卫生—外科学]