人体浮动基准位置的存在性研究  

Research on Existence of Floating Reference Position in Human Body

作　　者：王姣[1] 刘蓉[1] 于旭耀[1] 韩广[1] 徐可欣[1] 

机构地区：[1]天津大学精密测试技术及仪器国家重点实验室,天津300072

出　　处：《光学学报》2016年第6期316-324,共9页Acta Optica Sinica

基　　金：国家863计划(2012AA022602);国家自然科学基金(81471698;81401454)

摘　　要：提出了基于浮动基准位置的参考测量方法,有望实现血糖浓度的在体相对测量。基于定态漫射方程在半无限介质中的解析解,分析了浮动基准位置满足的函数关系式;基于Monte Carlo模拟方法,考察了三层皮肤模型在1000～1400nm波段内浮动基准位置的分布情况,同时分析了吸收系数和散射系数、表皮层和真皮层厚度对浮动基准位置的影响;搭建了基于超辐射发光二极管光源的多环光纤束检测系统,初步验证了浮动基准位置在人体中的存在性。模拟结果表明,三层皮肤模型在1000～1400nm波段内存在浮动基准位置且具有波长特性,散射系数变化对基准位置的影响大于吸收系数,表皮层厚度差异的影响大于真皮层。三位志愿者的在体实验表明,人体手掌在1050、1219、1314nm处均存在浮动基准位置,位于径向检测距离1.25～1.75mm之间,实验结果小于模拟结果,最大偏差达0.75mm。该结果对指导浮动基准测量光纤探头的设计具有一定参考价值。A measurement method based on the floating reference position is proposed, and the in vivo relative measurement of glucose concentration can be expected. The function of floating reference position is analyzed based on the analytieal solution to the steady state diffuse equation in a semi-infinite medium. Moreover, the distribution of floating reference position for the three-layer skin model within the wavelength of 1000-1400 nm is investigated based on the Monte Carlo simulation, as well as the influence of absorption coefficient, scattering coefficient, and thickness of epidermis and dermis on floating reference position. A customized optical fiber system with multiple circles based on the superluminescent diode is presented for initial validation of the existence of floating reference position in human body. The simulation results show that the reference positions of the three-layer skin model exist in the wavelength range of 1000-1400 nm and are wavelength dependent, the influence of scattering coefficient is stronger than that of absorption coefficient, and the influence of epidermis thickness variation is stronger than that of dermis thickness variation. The in vivo experiments on three volunteers show that floating reference positions of human palm at 1050, 1219, 1314 nm exist, and are located within the radial distance from 1.25 mm to 1.75 mm. The experimental results are lower than the simulation results, with a maximum bias of 0.75 ram. The result is valuable to the design of optical probe applied in the floating reference measurement.

关 键 词：光谱学 近红外光谱 人体浮动基准位置 浮动基准法 无创血糖检测 

分 类 号：O657.3[理学—分析化学]