心脏X综合征患者血浆脂蛋白相关磷脂酶A2水平的变化  

Changes of plasma lipoprotein-associated phospholipase A2 concentration in patients with cardiac syndrome X

作　　者：郝正阳[1] 李亚彭[1] 张彦周[1] 

机构地区：[1]郑州大学第一附属医院心血管内科,郑州450052

出　　处：《郑州大学学报（医学版）》2016年第3期413-415,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:分析心脏X综合征患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平变化的临床意义。方法:选择心脏X综合征患者52例作为病例组,健康人52例作为对照组。采用双抗体夹心免疫层析法测定2组血浆LpPLA2的水平;并同时测定血浆尿酸、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、C反应蛋白的水平。结果:与对照组相比,病例组血浆Lp-PLA2、TG、FBG均明显升高(P<0.05),病例组血浆Lp-PLA2与TC呈正相关(r=0.411,P=0.004),与HDL呈负相关(r=-0.610,P<0.001)。结论:血浆Lp-PLA2可以很好地反映血管病变情况,同时提示炎症参与了心脏X综合征的发生发展。Aim： To observe the changes of plasma lipoprotein-associated phospholipase A2（ Lp-PLA2） concentration and to analyze its significance in patients with cardiac syndrome X. Methods： A total of 52 patients with cardiac syndrome X were recruited as case group and 52 healthy subjects matched by age and gender were recruited as control group. The plasma Lp-PLA2 was detected by immunochromatography of double-antibody sandwich. Uric acid,total cholesterol（ TC）,triglyceride（ TG）,high density lipoprotein（ HDL）,low density lipoprotein（ LDL）,fasting blood glucose（ FBG） and C reactive protein in plasma were also determined. Results： The concentrations of plasma Lp-PLA2,TG and FBG were significantly higher in case group than those in control group（ P〈0. 05）. The plasma Lp-PLA2 was positively correlated with TC（ r = 0. 411,P = 0. 004）,and negatively correlated with HDL（ r =- 0. 610,P〈0. 001） in case group. Conclusion： The Lp-PLA2 may be a valuable biomarker of vasculopathy. Meanwhile,it suggests that inflammation may be involved in the development of cardiac syndrome X.

关 键 词：脂蛋白相关磷脂酶A2 心脏X综合征 

分 类 号：R541[医药卫生—心血管疾病]