Retrospective study of Traditional Chinese Medicine treatment of type 2 diabetes mellitus  

作　　者：Pang Bing Guo Jing Zhao Linhua Zhao Xiyan Zhou Qiang Tong Xiaolin 

机构地区：[1]Department of Endocrinology, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China [2]Beijing University of Traditional Chinese Medicine, Beijing 100029, China [3]Digestive Disease Diagnosis and Treatment Center, Beijing Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China

出　　处：《Journal of Traditional Chinese Medicine》2016年第3期307-313,共7页中医杂志（英文版）

基　　金：the National Basic Research Program of China(Study of Dose-effect Relationship of Classical Prescription,973 Program,No.2010CB530601)

摘　　要：OBJECTIVE: To provide clinical evidence in support of Dahuang Huanglian Xiexin decoction(DHXD) to treat type 2 diabetes mellitus(T2DM) and to introduce a new treatment option for clinicians.METHODS: Retrospective analysis was used to evaluate DHXD for the treatment of T2DM by analyzing clinical records of 183 cases. Patients with T2DM who met the inclusion criteria between January 1,2013 and January 1, 2014 were enrolled. The effects of the treatment were evaluated by the changes in fasting blood-glucose(FBG), postprandial blood sugar(PBG), hemoglobin A1c(Hb Alc), blood lipid profiles and body mass index(BMI) at 1, 2, 3 and 6 months. The changes in main symptoms were alsoevaluated. The dosage of Huanglian(Rhizoma Coptidis) and related factors were analyzed.RESULTS: There was a significant improvement in mean Hb A1C at 3 and 6 months after DHXD treatment compared with the baseline level(P < 0.01).There were also significant improvements in FBG,PBG, blood lipid series and BMI. DHXD also improved the main symptoms of stomach and intestine excessive heat syndrome in patients with obese T2DM. Huanglian(Rhizoma Coptidis) was the most frequently used in 678 clinical visits, the dosage of Huanglian(Rhizoma Coptidis) was related to age, BMI, DM duration, the level of blood glucose,and use of Western hypoglycemic drugs.CONCLUSION: This study suggests that DHXD could decrease blood glucose and improve T2DM symptoms and reduce body weight. The use of DHXD may indicate a new optional treatment for T2 DM.OBJECTIVE： To provide clinical evidence in support of Dahuang Huanglian Xiexin decoction（DHXD） to treat type 2 diabetes mellitus（T2DM） and to introduce a new treatment option for clinicians.METHODS： Retrospective analysis was used to evaluate DHXD for the treatment of T2DM by analyzing clinical records of 183 cases. Patients with T2DM who met the inclusion criteria between January 1,2013 and January 1, 2014 were enrolled. The effects of the treatment were evaluated by the changes in fasting blood-glucose（FBG）, postprandial blood sugar（PBG）, hemoglobin A1c（Hb Alc）, blood lipid profiles and body mass index（BMI） at 1, 2, 3 and 6 months. The changes in main symptoms were alsoevaluated. The dosage of Huanglian（Rhizoma Coptidis） and related factors were analyzed.RESULTS： There was a significant improvement in mean Hb A1C at 3 and 6 months after DHXD treatment compared with the baseline level（P 0.01）.There were also significant improvements in FBG,PBG, blood lipid series and BMI. DHXD also improved the main symptoms of stomach and intestine excessive heat syndrome in patients with obese T2DM. Huanglian（Rhizoma Coptidis） was the most frequently used in 678 clinical visits, the dosage of Huanglian（Rhizoma Coptidis） was related to age, BMI, DM duration, the level of blood glucose,and use of Western hypoglycemic drugs.CONCLUSION： This study suggests that DHXD could decrease blood glucose and improve T2DM symptoms and reduce body weight. The use of DHXD may indicate a new optional treatment for T2 DM.

关 键 词：Diabetes mellitus type 2 Blood glucose Body weight Dahuang Huanglian Xiexin decoction Retrospective studies 

分 类 号：R259[医药卫生—中西医结合]