二水二氯异氰尿酸钠消毒片对水中微生物杀灭效果及毒性研究  

Study on efficacy of sodium dichloroisocyanurate dihydrate aqua compound disinfection tablets in killing microorganisms in water and its toxicity

作　　者：崔玉杰[1] 韩艳淑[1] 左派欣[1] 孙克勤[1] 王茜[1] 张灵敏[1] 孙印旗[1] 

机构地区：[1]河北省疾病预防控制中心,河北石家庄050021

出　　处：《中国消毒学杂志》2016年第6期514-516,520,共4页Chinese Journal of Disinfection

摘　　要：目的了解二水二氯异氰尿酸钠消毒片溶液对水中微生物的杀灭效果、杀菌影响因素及其毒性,并与二氯异氰尿酸钠水消毒效果进行比较。方法应用定量杀菌试验、水消毒现场试验及动物毒性试验对二水二氯异氰尿酸钠消毒片水中微生物的杀灭效果及毒性进行研究。结果二水二氯异氰尿酸钠消毒片溶液在有效氯含量0.15 mg/L时,作用2 min,有效氯含量1.5 mg/L时,作用0.5 min,可使水中大肠杆菌降至0 cfu/100 ml,与二氯异氰尿酸钠杀菌结果基本一致;水温5℃-31℃、p H值6.5-8.5、色度〈15°,对有效氯含量1.5 mg/L作用30 min的杀菌效果无影响。有效氯含量1.5 mg/L作用30 min,可使游泳池水达合格标准。一次最大限度试验对小鼠LD_（50）〉5 000 mg/kg·bw（2 500 mg/L有效氯）,对皮肤刺激反应积分为0,小鼠骨髓嗜多染红细胞微核试验阴性。结论二水二氯异氰尿酸钠消毒片对水中微生物具有良好的杀菌效果,且属实际无毒、无刺激、无致突变作用,是一种较好的游泳池水消毒剂。Objective To know the efficacy of sodium dichloroisocyanurate dihydrate aqua compound disinfection tablets in killing microorganisms in water,and the influencing factors of germicidal efficacy and its toxicity.Methods Suspension quantitative germicidal test in laboratory,the influencing factors of germicidal efficacy test,the manual swimming pool water disinfection test and animal toxicity test were used out to study the germicidal efficacy of sodium dichloroisocyanurate dihydrate aqua compound disinfection tablets and its toxicity.Results The living colons number of Escherichia coli in water suspension decreased to 0 cfu /100 ml exposed to the sodium dichloroisocyanurate dihydrate aqua compound disinfection tablets water solution containing available chlorine 1.5 mg/L for 0.5 min or containing available chlorine 0.15 mg/L for 2min,which were in accordance with Sodium Dichloroisocyanurate disinfectant.The water temperature within 5℃ - 31℃,p H value within 6.5 - 8.5 and degree of color of organic substance 15° had no influence on germicidal efficacy of sodium dichloroisocyanurate dihydrate aqua compound disinfection tablets water solution containing available chlorine 1.5 mg/L for30 min.The wimming pool water was up- to- standard after disinfection with disinfectant containing available chlorine1.5 mg/L with a 30 min contact time and the residual chlorine was 0.5 mg/L.Its mouse oral LD_（50） was 5 000 mg/kg·bw and the average skin irritation score was 0,the mice marrow eosinophils polychromatic erythrocyte micronucleus test was negative.Conclusion The disinfection tablet has good efficacy in killing microorganisms in water and It＇s using concentration is actually non- toxic and non- irritative to skin and non- mutagenic.So it can be used for disinfection of swimming pool water.

关 键 词：二水二氯异氰尿酸钠消毒片 水消毒 影响因素 杀灭效果 游泳池水 毒性 

分 类 号：R187.1[医药卫生—流行病学]