瑞舒伐他汀治疗脑梗死急性期的疗效观察  

Observation on Efficacy of Rosuvastatin in Treatment of Acute Cerebral Infarction

作　　者：戴轶伟[1] 

机构地区：[1]南通市第三人民医院神经内科,江苏南通226006

出　　处：《中国医院用药评价与分析》2016年第6期773-775,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨瑞舒伐他汀治疗脑梗死急性期的抗炎效果及安全性。方法:选取2012年11月—2014年11月南通市第三人民医院收治的脑梗死急性期患者96例作为研究对象。以随机数字表法分为观察组和对照组各48例。在采用常规治疗的基础上,对照组患者给予辛伐他汀胶囊治疗;观察组给予瑞舒伐他汀钙片治疗,对治疗前后超敏C反应蛋白(hs-CRP)的变化情况进行比较。结果:观察组患者总有效率为97.9%(47/48),明显高于对照组的83.3%(40/48),差异有统计学意义(P<0.05);2组患者治疗前血清中hs-CRP的含量的差异无统计学意义(P>0.05),治疗6周后,2组患者的hs-CRP的含量较治疗前均有所下降,差异有统计学意义(P<0.05);观察组患者的不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:瑞舒伐他汀对脑梗死急性期的疗效显著,不良反应较少,具有临床意义。OBJECTIVE：To probe into the anti-inflammatory effects and safety of rosuvastatin in treatment of acute cerebral infarction .METHODS：96 patients with acute cerebral infarction admitted into the Third People ’s Hospital of Nantong from Nov.2012 to Nov.2014 were selected to be divided into observation group and control group via the random number table , with 48 cases in each .The control group were treated with Simvastatin capsules based on the conventional treatment , while the observation group received Rosuvastatin calcium tablets .Changes of hypersensitive C-reactive protein（hs-CRP） were researched and analyzed before and after treatment .RESULTS： The total effective rate of observation group was 97.9%（47/48）, significantly higher than that of control group [83.3%（40/48）], with statistically significant difference（P〈0.05）.There was no statistical significance for the content of serum hs-CRP in two groups（P〉0.05）.After treatment of 6 weeks, the content of serum hs-CRP decreased in two groups compared with before treatment , the difference was statistically significant （ P〈0.05 ） .The incidence of adverse drug reactions in observation group was significantly lower than that in control group , with statistical significance （ P 〈0.05 ） . CONCLUSIONS：The efficacy of rosuvastatin in treatment of acute cerebral infarction is significant , with few adverse drug reactions , and the application has important clinical significance .

关 键 词：脑梗死急性期 瑞舒伐他汀 抗炎作用 辛伐他汀 

分 类 号：R972.6[医药卫生—药品]