临床药师参与弥漫大B细胞淋巴瘤患者抗乙型肝炎病毒治疗的药学实践  

Pharmaceutical Care for Patients with Diffuse Large B-Cell Lymphoma in Anti-hepatitis B Virus Therapy by Clinical Pharmacists

作　　者：蒙光义[1,2] 黄立峰[1] 陈万生[1] 彭评志[2] 庞家莲[2] 

机构地区：[1]上海长征医院药学部,上海200003 [2]玉林市第一人民医院药学部,广西玉林537000

出　　处：《中国医院用药评价与分析》2016年第6期850-853,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解弥漫大B细胞淋巴瘤患者抗乙型肝炎病毒(hepatitis B virus,HBV)治疗的用药选择及药学监护。方法:介绍临床药师参与1例弥漫大B细胞淋巴瘤合并乙型肝炎病毒感染患者的抗病毒治疗过程,参考《美国国家综合癌症网络肿瘤学临床实践指南:非霍奇金淋巴瘤》《慢性乙型肝炎特殊患者抗病毒治疗专家共识:2014年》和相关文献,制订合理的抗HBV药物治疗方案。结果:结合患者的实际情况,临床药师依据指南和专家共识,建议临床医师选择恩替卡韦片作为患者抗HBV治疗用药,并对患者进行药学监护,避免了HBV再激活和爆发性乙型病毒性肝炎的发生,促进了化疗顺利完成。结论:恶心淋巴瘤患者化疗前应密切关注HBV的监测,正确、合理地选择抗HBV药,有利于促进化疗的顺利完成,保证用药安全、有效。OBJECTIVE：To investigate the drug selection and pharmaceutical care for patients with diffuse large B -cell lymphoma in anti-hepatitis B virus （ HBV） therapy .METHODS：The clinical pharmacists participated and evaluated the treatment process of anti-HBV therapy in diffuse large B-cell lymphoma patient .By referring to the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology：Non-hodgkin Lymphoma and Expert Consensus of Special Antiviral Treatment in Patients with Chronic Hepatitis B：2014 and the related literatures , the clinical pharmacists formulated rational anti-HBV medication regimens .RESULTS： Combined with the patients ’practical conditions , the clinical pharmacists advised the clinicians to use Entecavir tablets as anti -HBV medication and provided pharmaceutical care for patients according to the guidelines and expert consensus , so as to avoid HBV reactivation and explosive hepatitis B and promote the smooth completion of chemotherapy .CONCLUSIONS： The clinical pharmacists must pay more attention to the motoring of HBV in patients with diffuse large B-cell lymphoma , choose correct and rational anti-HBV to promote the smooth completion of chemotherapy , so as to ensure the safe and effective medication .

关 键 词：弥漫大B细胞淋巴瘤 乙型肝炎病毒 临床药师 药学监护 

分 类 号：R969.3[医药卫生—药理学] R97[医药卫生—药学]