养血清脑颗粒联合奥拉西坦治疗血管性认知障碍的疗效观察  

Clinical observation of Yangxue Qingnao Granules combined with oxiracetam in treatment of vascular cognitive impairment

作　　者：王真[1] 毕学超 崔会娟[1] 孙大宝[1] 杜金明[1] 刘保萍[1] 郭箭[2] 李文英[1] 崔松[1] 

机构地区：[1]华北石油管理局总医院神经内科,河北任丘062552 [2]华北石油管理局总医院保健科,河北任丘062552

出　　处：《现代药物与临床》2016年第6期805-809,共5页Drugs & Clinic

摘　　要：目的探讨养血清脑颗粒联合奥拉西坦胶囊治疗血管性认知障碍的临床疗效。方法选取华北石油管理局总医院2014年1月—2015年10月就诊的血管性认知障碍患者76例,随机数字表格法将患者分为对照组和治疗组,每组各38例。对照组患者口服奥拉西坦胶囊0.8 g/次,3次/d。治疗组在对照组治疗基础上口服养血清脑颗粒4 g/次,3次/d。两组患者均连续治疗3个月。观察两组的临床疗效,并比较两组治疗前后认知功能、局部脑血流量、睡眠障碍和事件相关电位P300。结果治疗后,对照组和治疗组总有效率分别为68.4%、94.7%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者简易精神智能量表(MMSE)评分明显上升,血管性痴呆评估量表-认知分量表(Va DAS-cog)评分明显下降,同组治疗前后比较差异具有统计学意义(P<0.05);治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组匹兹堡睡眠质量指数量表(PSQI)评分明显下降,同组治疗前后差异具有统计学意义(P<0.05);治疗组局部脑血流量、PSQI评分的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者事件相关单位P300潜伏期显著下降,波幅明显上升,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的幅度明显大于对照组,两组比较差异有统计学意义(P<0.05)。结论养血清脑颗粒联合奥拉西坦胶囊治疗血管性认知障碍具有较好的临床疗效,能够改善患者认知功能障碍,促进局部脑血流量增多,改善睡眠障碍和相关事件电位P300,具有一定的临床推广应用价值。Objective To observe the clinical effect of Yangxue Qingnao Granules combined with Oxiracetam Capsules in treatment of vascular cognitive impairment. Methods Patients（76 cases） with vascular cognitive impairment in North China Petroleum Hospital from January 2014 to October 2015 were divided into the control and treatment groups according to the random number table, and each group had 38 cases. The patients in control group were po administered with Oxiracetam Capsules, 0.8g/time, three times daily. The patients in the treatment group were po administered with Yangxue Qingnao Granules on the basis of the control group, 4 g/time, three times daily. The patients in two groups were treated for 3 months. After treatment, the efficacy was evaluated, and the changes of cognitive function, local cerebral blood flow, sleep disorder, and related event potential P300 were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 68.4% and 94.7%, respectively, and there were differences between two groups（P〈 0.05）. After treatment, MMSE scores in two groups were significantly increased, Va DAS-Cog score were significantly decreased, and the difference was statistically significant in the same group（P〈 0.05）. These observational indexes in treatment group were better than those in control group, with significant difference between two groups（P〈 0.05）. After treatment, PSQI score in treatment group was significantly decreased, and the difference was statistically significant in the same group（P〈 0.05）. Local cerebral blood flow and PSQI score in treatment group were better than those in control group, with significant difference between two groups（P〈 0.05）. After treatment, amplitude of related event potential P300 in two groups were significantly increased, latency of related event potential P300 were significantly decreased, and the difference was statistically significant in the same group（P〈 0.05）. These observational indexes in treatment gr

关 键 词：养血清脑颗粒 奥拉西坦胶囊 血管性认知障碍 认知功能 局部脑血流量 睡眠障碍 事件相关电位P300 

分 类 号：R971[医药卫生—药品]