通心络胶囊联合丁咯地尔治疗2型糖尿病下肢血管病变的临床研究  

Clinical study on Tongxinluo Capsules combined with buflomedil in treatment of lower extremity vascular lesionsin in type 2 diabetes

作　　者：熊红霞 陈维芊 陈文震 

机构地区：[1]柳州市工人医院(广西医科大学附属第四医院),广西柳州545005

出　　处：《现代药物与临床》2016年第6期815-818,共4页Drugs & Clinic

摘　　要：目的探讨通心络胶囊联合丁咯地尔治疗2型糖尿病下肢血管病变的的临床疗效。方法选取2015年3月—2016年3月在柳州市工人医院接受治疗的2型糖尿病下肢血管病变患者90例,根据治疗方案的不同分为对照组和治疗组,每组各45例。对照组静脉滴注盐酸丁咯地尔注射液,0.2 g加入5%葡萄糖溶液500 mL,1次/d。治疗组在对照组治疗的基础上口服通心络胶囊,4粒/次,3次/d。两组均连续治疗14 d。观察两组的临床疗效,同时比较两组治疗前后空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血浆黏度(CP)、血细胞比容(HCT)、血小板聚集率(PAR)、纤维蛋白原(FIB)、转化生长因子α(TNF-α)、白细胞介素6(IL-6)、高敏C反应蛋白(hs-CRP)、丙二醛(MDA)、超氧化物歧化酶(SOD)、踝肱指数(ABI值)和足背动脉管径的变化情况。结果治疗后,对照组和治疗组的总有效率分别为82.22%、95.56%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者FPG、2 hPG、HbAlc、IL-6、TNF-α、hs-CRP、MDA、CP、HCT、PAR、FIB水平均低于同组治疗前,SOD、ABI值、足背动脉管径高于同组治疗前,同组治疗前后差异有统计学意义(P<0.05);治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论通心络胶囊联合盐酸丁咯地尔治疗2型糖尿病下肢血管病变具有较好的临床疗效,可明显改善患者足背血流量和血液流变学指标,并可减轻机体炎症反应,具有一定的临床推广应用价值。Objective To investigate the clinical effect of Tongxinluo Capsules combined with buflomedil in treatment of lower extremity vascular lesionsin in type 2 diabetes. Methods Patients（90 cases） with lower extremity vascular lesionsin in type 2 diabetes in the Liuzhou Worker＇s Hospital from March 2015 to March 2016 were divided into control group（45 cases） and treatment group（45 cases） according to different treatment plans. The patients in the control group were iv administered with Buflomedil Hydrochloride Injection, 0.2 g added into 5% glucose solution 500 mL, once daily. The patients in the treatment group were po administered with Tongxinluo Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of FBG, 2 hPG, HbA1c, CP, HCT, PAR, FIB, TNF-α, IL-6, hs-CRP, MDA, SOD, ABI score, and dorsalis pedis artery diameter in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control group and treatment group were 82.22% and 95.56%, respectively, and there were differences between two groups（P〈 0.05）. After treatment, FPG, 2 hPG, HbAlc, IL-6, TNF-α, hs-CRP, MDA, CP, HCT, PAR, and FIB in two groups were significantly decreased, and SOD, ABI, and dorsalis pedis artery diameter in two groups were significantly increased, and the difference was statistically significant in the same group（P〈 0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈 0.05）. Conclusion Tongxinluo Capsules combined with buflomedil has good clinical efficacy in treatment of lower extremity vascular lesionsin in type 2 diabetes, and can obviously improve the foot back blood flow and blood rheology indicators, and can reduce the inflammatory response, which has a certain clinical application value.

关 键 词：通心络胶囊 盐酸丁咯地尔注射液 2型糖尿病 下肢血管病变 糖化血红蛋白 踝肱指数 足背动脉管径 

分 类 号：R977[医药卫生—药品]