活血止痛软胶囊联合骨肽治疗膝骨性关节炎的临床研究  

Clinical study on Huoxue Zhitong Capsules combined with ossotide in treatment of knee osteoarthritis

作　　者：黄凯[1] 唐旭东[1] 

机构地区：[1]内江市第一人民医院,四川内江641000

出　　处：《现代药物与临床》2016年第6期838-841,共4页Drugs & Clinic

摘　　要：目的探讨活血止痛胶囊联合骨肽注射液治疗膝骨性关节炎的临床疗效。方法选取2015年1月—2016年1月在内江市第一人民医院骨科接受治疗的膝骨性关节炎患者78例,根据治疗方案的不同分为对照组(39例)和治疗组(39例),对照组关节腔注射骨肽注射液,30 mg/次,1次/周;治疗组在此基础上口服活血止痛胶囊,6粒/次,2次/d。两组患者均连续治疗4周。比较两组患者治疗前后总有效率。观察两组治疗前后Lequesne指数和视觉模拟分数变化情况,同时检测两组治疗前后血清IL-1β、TNF-α、MMP-9和NO水平改变。结果治疗后,对照组和治疗组总有效率分别为79.49%和94.87%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者Lequesne指数和视觉模拟分数均明显降低(P<0.05),但治疗组降低的更明显,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清IL-1β、TNF-α、MMP-9和NO水平均明显降低(P<0.05),但治疗组降低的更明显,两组比较差异具有统计学意义(P<0.05)。结论活血止痛胶囊联合骨肽注射液治疗膝骨性关节炎疗效显著,可明显改善患者膝关节功能和减轻关节疼痛及降低血清炎性因子水平,具有一定的临床推广应用价值。Objective To investigate the clinical efficacies of Huoxue Zhitong Capsules combined with Ossotide Injection in the treatment of knee osteoarthritis. Methods Patients（78 cases） with knee osteoarthritis in the First People＇s Hospital of Neijiang from January 2015 to January 2016 were divided into control group（39 cases） and treatment group（39 cases） according to different treatment plans. The patients in the control group were intra-articular injected with Ossotide Injection, 30 mg/time, once a week. The patients in the treatment group were po administered with Huoxue Zhitong Capsules on the basis of the control group, 6 grains/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, clinical efficacies between two groups were compared. And the changes of Lequesne indexes and visual analogue scores in two groups were observed. Equally, the levels of blood IL-1β, TNF-α, MMP-9 and NO in two groups before and after treatment were detected. Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 94.87%, respectively, and there were differences between two groups（P〈 0.05）. After treatment, Lequesne indexes and visual analogue scores in two groups were significantly decreased（P〈 0.05）. Furthermore, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈 0.05）. After treatment, the levels of blood IL-1β, TNF-α, MMP-9, and NO in two groups were significantly decreased（P〈 0.05）, and the reductions in treatment group were more obvious, with significant difference between two groups（P〈 0.05）. Conclusion Huoxue Zhitong Capsules combined with Ossotide Injection has significant clinical efficacies in the treatment of knee osteoarthritis, can improve knee joint functions and reduce joint pains and inflammatory factors levels in serum, which has a certain clinical application value.

关 键 词：活血止痛胶囊 骨肽注射液 膝骨性关节炎 临床疗效 

分 类 号：R976[医药卫生—药品]