尘螨变应原皮肤点刺试验等级对特异性免疫治疗效果的影响  

Influence of specific immunotherapy in allergic rhinitis children with different level of sk in prick test with dermatophagoides allergens

作　　者：郭杰峰[1] 伍慧卿[1] 林丽莉[1] 赵晓明[1] 熊彬彬[1] 刘钊[1] 

机构地区：[1]暨南大学医学院第三附属医院珠海市人民医院耳鼻咽喉科,广东珠海519000

出　　处：《中国耳鼻咽喉头颈外科》2016年第6期345-348,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的观察粉尘螨、屋尘螨变应原皮肤点刺试验（skin prick test,SPT）等级不同的变应性鼻炎患儿应用安脱达和阿罗格标准化尘螨疫苗进行特异性免疫治疗（specific immunotherapy,SIT）的疗效。方法将确诊为持续性变应性鼻炎的6~12岁患儿按SPT等级分3组,I组：粉尘螨皮肤指数（skin index,SI）大于屋尘螨组,II组：粉尘螨SI等于屋尘螨组,III组：粉尘螨SI小于屋尘螨组。再采用随机分组方法将每组内患儿分为安脱达组和阿罗格组,并给予相应药物SIT 1年,观察记录并分析比较患者症状得分及药物评分。结果 I、II组患者治疗3个月、6个月时症状得分及药物评分改善情况阿罗格组优于安脱达组,2组间差异有统计学意义（P〈0.05）;III组患者治疗3个月、6个月时症状得分及药物评分改善情况安脱达组优于阿罗格组,2组间差异有统计学意义（P〈0.05）;I、II、III组患者治疗9个月、12个月时安脱达组和阿罗格组症状得分及药物评分改善情况差异无统计学意义（P〉0.05）。结论粉尘螨、屋尘螨SPT等级不同的变应性鼻炎患儿应用安脱达和阿罗格标准化尘螨疫苗进行SIT 3个月、6个月时疗效不同,9个月、12个月时疗效一致,两者均是治疗变应性鼻炎的有效药物。OBJECTIVE To observe the efficacy of specific immunotherapy（SIT） with Alutard and NHD in children with allergic rhinitis due to different level of skin prick test（SPT） with dermatophagoides farinae（DF） and dermatophagoides pteronyssinus（DP）.METHODS A total of 178 children with persistent allergic rhinitis were included in this study.Their age ranged from 6 to 12 years.They were divided into 3 groups according to level of SPT.Group 1：The level of skin index（SI） of DF is greater than that of DP,Group 2：The level of SI of DF is equal to that of DP and Group 3：The level of SI of DF is less than that of DP.The children in each group were randomly divided into2 subgroups：Alutard group and NHD group.The children were given SIT with Alutard or NHD for one year.Symptom and medication scores were recorded and analyzed.RESULTS After receiving therapy for 3 months and 6months,symptom and medication scores of the Group 1 and2 in the NHD group were lower than those in the Alutard group（P〈0.05）;Symptoms and medication scores of the Group 3 in the Alutard group were lower than those in the NHD group（P〈0.05）.After receiving therapy for 9 and 12 months,the symptom and medication scores of the NHD and Alutard group in all the three groups showed no statistical difference（P〉0.05）.CONCLUSION The efficacy of SIT with Alutard and NHD is different in children with allergic rhinitis with different levels of SPT due to DF and DP after3 and 6 months,but is similar after 9 and 12 months.SIT with Alutard and NHD is effective in treating children with allergic rhinitis.

关 键 词：鼻炎 变应性 常年性 脱敏法 免疫 皮肤试验 治疗结果 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]