Maspin在侵袭型真菌性鼻-鼻窦炎中表达的研究  

Expression of Maspin in invasive fungal rhinosinusitis

作　　者：虞和伟 康宗辉[2] 潘丹 夏思文[2] 胡献惠[2] 陈英武[1] 何云生[1] 黄益灯[2] 

机构地区：[1]浙江省湖州市中心医院耳鼻咽喉科,浙江湖州313000 [2]解放军第一一八医院耳鼻咽喉头颈外科,浙江温州325000 [3]温州市人民医院病理科,浙江温州325000

出　　处：《中国耳鼻咽喉头颈外科》2016年第6期349-352,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的检测侵袭型真菌性鼻-鼻窦炎中Maspin的表达,探讨其对侵袭型真菌性鼻-鼻窦炎的诊断价值。方法选取真菌性鼻-鼻窦炎标本42例为实验组,包括12例侵袭型与30例非侵袭型;慢性鼻-鼻窦炎30例为对照组。免疫组化法检测标本中Maspin的表达。结果真菌性鼻-鼻窦炎组Maspin表达下调,与对照组比较,差异有统计学意义(P<0.05);侵袭型真菌性鼻-鼻窦炎组Maspin评分最低,与非侵袭型及对照组两组分别比较,差异均有统计学意义(P<0.05)。取Maspin评分5.70为临界值,诊断侵袭型真菌性鼻-鼻窦炎敏感性为91.7%,特异性为88.3%。结论 Maspin在侵袭型真菌性鼻-鼻窦炎中表达下调。Maspin可能是诊断侵袭型真菌性鼻-鼻窦炎的重要指标。OBJECTIVE To explore the expression of Maspin in invasive fungal rhinosinusitis（IFRS） and the value of Maspin in the diagnosis of IFRS.METHODS Forty two cases of fungal rhinosinusitis（FRS） were set as the experimental group,which included 12 cases of IFRS and 30 cases of noninvasive fungal rhino-sinusitis（NIFRS）.At the same time,30 cases of chronic rhino-sinusitis were set as control group.Immunohistochemistry（IHC） was used to detect the expression of Maspin.RESULTS Compared with the control group,the expression of Maspin in FRS group decreased statistically（t=-3.367,P〈0.05）.The IFRS group,compared with other two groups,had the lowest expression of Maspin（t=-3.390,P〈0.05;t=-4.143,P〈0.05）.By using Maspin score of 5.70 as the cut-off point,the sensitivity and specificity for the diagnosis of IFRS was 91.7%and 88.3%respectively.CONCLUSION The expression of Maspin is very low in IFRS group.Down-regulation of Maspin expression may be a potential indicator for diagnosis of IFRS.

关 键 词：免疫组织化学 真菌病 鼻窦炎 侵袭性 MASPIN 

分 类 号：R765[医药卫生—耳鼻咽喉科]