正交设计优选皂矾洗剂的水提工艺  

Optimization of Water-Extraction Technology of Melanterite Lotion by Orthogonal Design

作　　者：陈珂 黄锐 任桂林 赵剑 明俊男 杨文信 杨春艳 蒲清荣 

机构地区：[1]四川省泸州市食品药品检验所,四川泸州646000 [2]西南医科大学附属中医医院,四川泸州646000

出　　处：《中国药业》2016年第13期37-39,共3页China Pharmaceuticals

摘　　要：目的优选皂矾洗剂的提取工艺。方法以苦参碱为指标,对加水量、浸泡时间、提取时间、提取次数4个影响因素进行考察,采用正交试验法优选皂矾洗剂的提取工艺。结果皂矾洗剂的最佳水提工艺是,按处方比例称取药材,加入10倍量水,浸泡1.5 h,提取3次,每次1 h。结论优选的水提工艺简单可行,稳定可靠,具可操作性和重复性。Objective To optimize the preparation technology of melanterite lotion. Methods The contents of matrine was taken as the indexes, the factors of the amount of water, time of soaking and extraction, and extraction times were investigated. Orthogonal design was used to optimize the prepartion technology for extrating melanterite lotion. Results The optimal preparation technology was as follows：adding 10 folds of water, soaking for 1. 5 h, extracting 3 times, 1 h/time. Conclusion The optimized preparation technology for melanterite lotion is reasonable, feasible, stable, reliable and has good reproducibility.

关 键 词：皂矾洗剂 水提工艺 正交设计 苦参碱 

分 类 号：TQ461[化学工程—制药化工] R286.0[医药卫生—中药学]