血脂宁药理毒理学研究进展  

Research Progress on Pharmacology and Toxicology of Xuezhining

作　　者：石亮[1,2] 黄娜娜[1,2] 孙蓉[1] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东中医药大学,山东济南250355

出　　处：《中国药物警戒》2016年第6期347-350,共4页Chinese Journal of Pharmacovigilance

基　　金：国家发改委中医药行业专项(201507004-07);山东省自主创新和成果转化项目(2014ZZCX02104)

摘　　要：目的通过对血脂宁相关制剂近10年来的药理毒理学研究进展进行总结与分析,为进一步合理应用血脂宁提供文献依据。方法对国内外近10年来发表的血脂宁相关制剂研究文献进行归纳、总结、分析。结果血脂宁具有降血脂、防治动脉粥样硬化和抗心绞痛的作用,对于动脉粥样硬化导致的冠心病、心律失常等疾病有一定的治疗作用。其药理作用为增强冠状动脉的血液循环,软化血管,提高心肌对强心苷作用的敏感性,抗心律失常及高脂血症;其降脂机制是降低血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平,并升高高密度脂蛋白胆固醇(HDL-C)水平,临床未发现其毒性及副作用报道。结论血脂宁通过抑制人体内胆固醇和甘油三酯的吸收、分解、排泄及其在血管壁沉积等不同途径影响血脂代谢,并可降低高脂血症患者的血液黏度,目前尚未检索到相关的毒副作用报道。Objective To provid references for further rational drug use through summarizing and analyzing the research progress of the related pharmacology of Xuezhining related preparations in recent 10 years.Methods References in the last decades at home and abroad about Xuezhining related preparations were collated, analyzed and summarized.ResultsXuezhining has been used for the treatment of hyperlipidemia, atherosclerosis and angina. In addition, it still has a certain effect in coronary heart disease and arrhythmia which caused by atherosclerosis. Its pharmacological effects are enhancing coronary blood circulation, softening blood vessels, improving myocardial sensitivity to cardiac glycoside action, against arrhythmia and hyperlipidemia. Its lipid-lowering mechanism is lowering plasma total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） levels and increasing high-density lipoprotein cholesterol （HDL-C） levels. There was no clinical toxicity and side effects reported.Conclusion Xuezhining affects the metabolism of lipids and reduces blood viscosity in patients with hyperlipidemia by inhibiting the body’s absorption, decomposition, excretion and deposition in the vascular wall of cholesterol and triglycerides in different ways. There were no toxic side effects reported yet.

关 键 词：血脂宁 药理 毒理 

分 类 号：R965[医药卫生—药理学] R286[医药卫生—药学]