Controlled Synthesis of PCL/PVP Copolymer by RAFT Method and Its HydrophUic Block-Dependent MiceUar Behaviors  

RAFT控制合成PCL／PVP共聚物及其胶束行为的亲水链依赖性

作　　者：李蕤[1] 庞文民[3] 朱清仁[3] 聂康明[2] 

机构地区：[1]合肥学院生物与环境工程系,合肥230022 [2]安徽大学化学化工学院,安徽省高分子绿色材料重点实验室,合肥230601 [3]中国科学技术大学合肥微尺度物质科学国家实验室,合肥230026

出　　处：《Chinese Journal of Chemical Physics》2016年第3期358-364,I0002,共8页化学物理学报（英文）

摘　　要：A range of poly（ε-caprolactone）/poly（N-vinyl-2-pyrrolidone） amphiphilic block copolymers with well-defined hydrophilic chain length were synthesized by the living/controlled reversible addition fragmentation chain transfer polymerization method. The composition and struc- ture of the targeted resultants were characterized with 1H NMR, 13C NMR, FT-IR spec- troscopy and gel permeation chromatography. The various block copolymers were success- fully employed to fabricate the spherical micelle with core-shell morphological structure. The poly（N-vinyl-2-pyrrolidone） block-dependent characteristics of the copolymeric micelles were investigated by fluorescence spectroscopy, dynamic light scattering, and transmission electron microscopy. The solubilization of the hydrophobic ibuprofen as a model drug in the micelle solution was also explored. It was found that the drug loading contents are related to the micellar morphology structure determined by hydrophilic chain length in the copolymer.

关 键 词：RAFT polymerization Poly（N-vinyl-2-pyrrolidone） Core-shell structure Hydrophilic chain length Micellar behavior 

分 类 号：O[理学]