高胆红素血症患儿ABO新生儿溶血病发病率及其相关因素分析  

Incidence of ABO hemolytic disease of newborns with hyperbilirubinemia and its correlation factors

作　　者：刘帅[1] 张晨光[2] 申家辉[1] 

机构地区：[1]新乡医学院第三附属医院输血科,河南新乡453003 [2]新乡医学院医学检验学院,河南新乡453003

出　　处：《新乡医学院学报》2016年第6期521-523,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨高胆红素血症患儿ABO新生儿溶血病(HDN)(ABO-HDN)的发病率,并分析与ABO-HDN发病相关的因素。方法选择311例高胆红素血症新生儿静脉血标本进行ABO和Rh D血型鉴定及新生儿溶血3项试验检测。结果 311例高胆红素血症新生儿中,确诊ABO-HDN患者97例,阳性率为31.19%,其中直接抗球蛋白试验阳性者56例(57.73%),游离试验阳性者61例(62.89%),放散试验阳性者97例(100.00%)。患儿血型A型的阳性率为59.80%(61/102),高于B型的38.71%(36/93)(χ2=10.230,P<0.05)。ABO-HDN阳性患儿血清总胆红素为(315.27±84.16)μmol·L^(-1),高于阴性患儿的(274.52±75.93)μmol·L^(-1)(t=4.158,P<0.05)。结论高胆红素血症患儿ABO-HDN发病率较高,患儿的血型和血清总胆红素是与ABO-HDN发病密切相关的2个因素。Objective To explore the incidence of ABO hemolytic disease of newborns（ HDN）（ ABO-HDN） with hyperbilirubinemia and analyze the related factors of ABO-HDN. Methods The venous blood samples of 311 newborns with hyperbilirubinemia were analyzed by ABO and Rh D blood typing and three tests of ABO hemolysis. Results Among 311 cases of hyperbilirubinemia,97 cases were definitely diagnosed with ABO-HDN（ 31. 19%）,in which the direct antiglobulin test,free antibody test and antibody release test were positive in 56 cases（ 57. 73%）,61 cases（ 62. 89%） and 97 cases（ 100. 00%） respectively. The positive rate of patients with type A blood typing（ 59. 80%） was higher than type B blood typing（ 38. 71%）（ χ^2= 10. 230,P〈0. 05）. The serum total bilirubin value of newborns with ABO-HDN [（ 315. 27 ± 84. 16） μmol·L^-1]was significantly higher than that of newborns without ABO-HDN[（ 274. 52 ± 75. 93） μmol·L^-1]（ t = 4. 158,P〈0. 05）. Conclusion ABO-HDN incidence of newborns with hyperbilirubinemia is higher; the blood type and serum total bilirubin values are two closely related factors of ABO-HDN.

关 键 词：高胆红素血症 新生儿溶血病 溶血3项试验 

分 类 号：R725.4[医药卫生—儿科]