肿瘤细胞间相互作用：Notch-1信号转导与调控机制  

Cancer cell-cell interaction: Notch-1 signaling pathway and its regulation mechanisms

作　　者：李莉[1] 熊妮娅 张婧[1] 杨红[1] 吴春惠[1] 刘贻尧[1] 

机构地区：[1]电子科技大学生命科学与技术学院,生物物理系,成都610054

出　　处：《医用生物力学》2016年第3期284-290,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11272083,31470906,11502049);四川省杰出青年基金项目(2014JQ0008)

摘　　要：Notch-1信号通路在细胞分化、发育以及增殖、凋亡方面起重要作用,并参与肿瘤的发生发展,与肿瘤的侵袭、运动和转移过程密切相关。活化的Notch-1信号通路能够直接或间接调控细胞的增殖和迁移,促进肿瘤细胞发生上皮细胞间充质转换,并维持其间充质特性,增强肿瘤细胞的黏附能力。同时,Notch信号通路与PI3K/Akt、NF-κB等途径交互作用,将信号级联放大,从而加强调控肿瘤细胞的恶性行为。多种实体瘤中存在异常活化的Notch-1信号通路。从Notch的结构和功能、Notch-1信号通路与肿瘤发生和转移的关系、Notch-1调控肿瘤转移的分子机制与调控网络和以Notch为靶点的肿瘤治疗5个方面进行综述。阐明Notch-1信号通路在肿瘤转移过程中的作用与调控机制以及目前针对Notch-1信号通路的治疗策略,能够为肿瘤的病理机制和临床治疗研究提供参考信息。Notch-1 signaling pathway is responsible for cell differentiation,development,proliferation and apoptosis. Recent studies show that Notch-1 signaling pathway is also involved in cancer progression,including cell invasion,motility and cancer metastasis. Activation of Notch-1 signaling pathway can directly or indirectly induce cell proliferation and migration. In tumor cells,activation of Notch-1 facilitates epithelial-mesenchymal transition（ EMT）,keeps its mesenchyme characteristics and induces cell adhesion. Notch-1 signaling pathway also crosstalks with other pathways to regulate cell fate,such as PI3 K / Akt,NF-κB pathways. The evidence shows that aberrant Notch-1 activation has been found in different solid tumors,which participates in regulating tumor metastasis. In this review,the Notch structure and function,Notch-1 signal and tumorigenesis,tumor metastasis via Notch-1 signaling,and Notch-1 signaling targeted-therapy were comprehensively summarized. To clarify the roles of Notch-1 signal pathway in tumor metastasis and its regulatory mechanisms as well as the current treatment strategies for Notch-1 signal pathway will provide references for studies on pathomechanism and clinical treatment of cancers.

关 键 词：Notch-1信号通路 细胞间相互作用 肿瘤细胞 细胞黏附 肿瘤转移 

分 类 号：R318.01[医药卫生—生物医学工程]