异丙酚复合芬太尼用于老年患者无痛胃镜检查的临床效果探讨  

Discussion on clinical effect of propofol combined with fentanyl in elderly patients with painless gastroscopy

作　　者：杨丹[1] 余庆波[1] 王艺铮[1] 

机构地区：[1]川北医学院麻醉学系,四川南充637000

出　　处：《现代医药卫生》2016年第13期1991-1993,共3页Journal of Modern Medicine & Health

摘　　要：目的：探讨异丙酚复合芬太尼用于老年患者无痛胃镜检查的临床效果。方法选取2013年1月至2015年12月在该院接受无痛胃镜检查的老年患者180例作为研究对象，将其分为观察组和对照组，每组90例。对照组给予0.03～0.04 mg/kg咪达唑仑（咪唑安定）和1～2 mg/kg异丙酚，观察组给予0.5μg/kg芬太尼和1～2 mg/kg异丙酚，均采用静脉注射。监测两组患者脉搏血氧饱和度（SpO2）、血压、心电图等变化，并观察其不良反应。结果给药后观察组患者平均动脉压（MP）为（70.5±2.8）mm Hg（1 mm Hg=0.133 kPa），对照组为（73.5±3.5）mm Hg；观察组患者心率（HR）为（70.1±8.6）次/分，对照组为（72.6±10.2）次/分；两组患者MP及HR比较，差异均无统计学意义（P＞0.05）。观察组患者SpO2[（95.5±2.5）%]高于对照组[（91.0±3.0）%]，苏醒时间[（10.1±1.3）mim]短于对照组[（15.3±1.2）min]，检查过程中呛咳和低氧血症发生率[3.3%（3/90）、0.0%（0/90）]均明显低于对照组[13.3%（12/90）、4.4%（4/90）]，差异均有统计学意义（P〈0.05）。结论异丙酚复合芬太尼用于老年患者无痛胃镜检查安全，临床效果相对较好。Objective To investigate the clinical effect of propofol combined with fentanyl in elderly patients with pain-less gastroscopy. Methods A total of 180 elderly patients with painless gastroscopy in this hospital from January 2013 to De-cember 2015 were selected as the research subjects and randomly divided into two groups ,90 cases in each group. The control group was given 0.03-0.04 mg/kg midazolam and 1-2 mg/kg propofol,while the observation group received 0.5μg/kg fentanyl and 1-2 mg/kg propofol,which adopted intravenous injection. The changes of blood oxygen saturation（SpO2）,blood pressure and ECG were monitored. The adverse reactions were observed. Results After drug administration,mean arterial pressure（MAP） in the observation group was （70.5±2.8）mmHg（1 mm Hg=0.133 kPa）,which in the control group was（72.5±3.4）mmHg;the heart rate （HR）was （70.1±2.6）bpm in the observation group and（72.6±3.2）bpm in the control group,showing that MP and HR had no sta-tistical differences between the two groups（P〉0.05）;SpO2 in the observation group was（95.5±2.5）%,which was higher than （91.0±3.0）%in the control group,the awake time in the observation group was（10.1±1.3）min,which was shorter than（15.3± 1.2）min in the control group,the occurrence rates of bucking and hypoxemia in the observation group were significantly lower than those in the control group[3.3%（3/90）,0.0%（0/90）vs. 13.3%（12/90）,4.4%（4/90）,P〈0.05],the differences were statisti-cally significant. Conclusion Application of propofol combined with fentanyl in elderly patients with painless gastroscopy is safe with relatively good clinical effect.

关 键 词：二异丙酚 芬太尼 麻醉 静脉 胃镜检查 老年人 无痛胃镜 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]