富血小板纤维蛋白在临床医学中的应用研究进展  

Recent progress on the application of platelet-rich fibrin in clinical medicine

作　　者：朱卫丽[1] 薛小萍[1] 刘衍春[2] 

机构地区：[1]江苏省苏北人民医院输血科,江苏扬州225001 [2]江苏省血液中心

出　　处：《中国输血杂志》2016年第5期545-548,共4页Chinese Journal of Blood Transfusion

基　　金：江苏省自然科学基金(BK20151310)

摘　　要：富血小板纤维蛋白(PRF)被誉为第二代富血小板浓缩物,是自体血液经离心而获得。通过血小板生长因子、白细胞因子和纤维蛋白基质的共同作用,PRF可在血管生成、组织再生和骨组织愈合中发挥重要的作用。作为1种新型再生医学材料,PRF已被逐渐用于口腔颌面部外科、整形外科、运动医学、耳外科和泌尿外科中。本文就PRF在临床医学中的最新应用进展作一综述。Platelet-rich fibrin（ PRF）,also known as the second generation of platelet concentrate,is prepared from autologous blood by centrifugation. PRF has been demonstrated to induce positive effects on stimulating angiogenesis and accelerating soft and hard tissue healing. The positive effects should be attributed to the combined actions of platelet growth factor,leucocyte cytokines and fibrin matrix. As a novel material in regenerative medicine,PRF has been widely used in oral and maxillofacial surgery,plastic surgery,sports medicine,otology and urology surgery. This article serves as an introduction to the recent advance of PRF applied in clinical medicine.

关 键 词：富血小板纤维蛋白 机制 临床医学 应用 

分 类 号：R457.1[医药卫生—治疗学] R331.143[医药卫生—临床医学]