脂肪因子与心肌重构相关性的研究进展  被引量:3

Research Progress of Correlation between Adipocytokines and Myocardial Remodeling

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作  者:费俊杰[1] 赖应龙[1] 

机构地区:[1]川北医学院附属医院心胸外科,四川南充637000

出  处:《中国胸心血管外科临床杂志》2016年第7期742-745,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基  金:四川省教委资助项目(12ZA055)~~

摘  要:心肌重构是多种心脏疾病共同的病理生理改变,在压力或缺血等刺激下,机体释放多种细胞因子,促进心肌结构改变,最终导致心衰。心肌重构主要包括心肌细胞重构和心肌细胞外基质重构。近年来发现,脂肪组织不仅具有储能、缓冲保护和支持填充等作用,还具有强大的内分泌功能,可分泌多种脂肪因子,包括瘦素、脂联素、内脂素、网膜素、血管紧张素Ⅱ等。目前,有研究表明脂肪因子与心肌重构有着密切关系,本文将对这些因子在心肌重构中的作用做出综述。Myocardial remodeling is a common pathological physiology change for a variety of heart diseases under stimulation such as stress or ischemia. The engine body will release a lot of cytokines to promote the change of myocardial structure and ultimately lead to heart failure. Myocardial remodeling includes myocardial cells remodeling and the extracellular matrix remodeling. In recent years, we find that the function of adipose tissue is not only about energy storage, buffering to protect, supporting and filling, but also has a powerful function of secretion. Adipose tissue can secrete various adipocytokines, such as leptin, adiponectin, visfatin, omentin, angiotensin II, and so on. Current studies have shown that adipocytokines and myocardial remodeling are intimated. And this article will summarize the function of adipocytokines on myocardial remodeling.

关 键 词:心肌重构 脂肪因子 瘦素 脂联素 内脂素 

分 类 号:R54[医药卫生—心血管疾病]

 

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