冠脉介入术患者医院感染免疫指标分析  

Immune indexes of nosocomial infections for patients undergoing coronary intervention

作　　者：张春德[1] 刘利军[1] 洪德瑞[2] 曾昭波[1] 刘营[1] 

机构地区：[1]淮南市第一人民医院心内科,安徽淮南232007 [2]淮南市第一人民医院急诊科,安徽淮南232007

出　　处：《中华医院感染学杂志》2016年第13期2966-2968,共3页Chinese Journal of Nosocomiology

基　　金：安徽省卫生厅医学科研基金资助项目(A2010151)

摘　　要：目的探讨冠脉介入术患者预防性应用抗菌药物对术后感染的影响,为临床合理应用抗菌药物提供参考依据。方法选取2012年2月-2013年4月医院收治行冠脉介入术的患者136例,将其随机分为两组,每组68例。观察组术前1h预防性应用适量抗菌药物,对照组术前不应用抗菌药物,对比两组术后相关症状、感染的发生情况及住院时间、住院费用等。结果观察组与对照组患者术后发热、C-反应蛋白升高、白细胞增多、中性粒细胞增加、术后感染、疑似感染发生率、住院时间比较,差异均无统计学意义;但观察组患者住院费用高于对照组,差异有统计学意义(P<0.05)。结论冠脉介入术预防性应用抗菌药物与术后感染的发生无明显相关性,但增加治疗费用,故临床无需预防性应用抗菌药物,可在一定程度上降低耐药性,促使抗菌药物合理应用。OBJECTIVE To explore the influence of prophylactic use of antibiotics on postoperative infections in patients undergoing coronary intervention so as to provide guidance for reasonable clinical use of antibiotics.METHODS A total of 136 patients who underwent the coronary intervention in the hospital from Feb 2012 to Apr2013were enrolled in the study and randomly divided into two groups,with 68 cases in each group.The observation group was treated with appropriate dose of antibiotics for prophylaxis at one hour before surgery,while the control group was not given antibiotics.The postoperative symptoms,incidence of infections,length of hospital stay,and hospitalization cost were observed and compared between the two groups of patients.RESULTS There was no significant difference in the postoperative fever,elevated C-reactive protein,leukocytosis,increase of neutrophils,incidence of postoperative infections or suspected infections,or length of hospital stay between the observation group and the control group;however,the hospitalization cost of the observation group was significantly higher than that of the control group（P〈0.05）.CONCLUSION The incidence of the postoperative infections in the patients undergoing the coronary intervention is not significantly associated with the prophylactic use of antibiotics but may lead to the increase of treatment cost,therefore,the antibiotic prophylaxis is not necessary in the hospital,which may reduce the drug resistance to some extent and facilitate the reasonable use of antibiotics.

关 键 词：冠脉介入术 抗菌药物 术后感染 应用研究 

分 类 号：R654.2[医药卫生—外科学]