甲状腺术后切口感染抗坏血酸克吕沃尔菌伴窦道经久不愈的临床治疗效果观察  

Observation of clinical treatment of patients with Kluyvera ascorbata caused infections with long time unhealed sinus after thyroid surgeries

作　　者：薛福珍[1] 李芹[1] 郑文[1] 柳莉[1] 于淑芹[1] 

机构地区：[1]山东省交通医院医院感染管理科,山东济南250031

出　　处：《中华医院感染学杂志》2016年第13期3028-3030,共3页Chinese Journal of Nosocomiology

基　　金：山东省卫生厅专项基金资助项目(HS-2010AW-047)

摘　　要：目的研究甲状腺术后切口感染抗坏血酸克吕沃尔菌伴窦道经久不愈的临床治疗效果,为临床提供依据。方法选取2012年10月-2015年11月医院诊治的甲状腺术后切口感染抗坏血酸克吕沃尔菌伴窦道经久不愈患者50例,根据随机数字方法分为对照组与试验组,每组25例,对照组采用常规抗菌药物治疗,试验组在对照组治疗基础上行手术治疗,比较两组临床疗效。结果试验组总有效率为92.0%,显著高于对照组的72.0%(P<0.05);两组患者治疗前血清人白介素-5(IL-5)及血清人白介素-8(IL-8)水平差异无统计学意义;试验组治疗后IL-5及血清人白介素-8(IL-8)水平,显著低于对照组(P<0.05);试验组并发症发生率为8.0%,显著低于对照组的36.0%(P<0.05)。结论甲状腺术后切口感染抗坏血酸克吕沃尔菌伴窦道经久不愈患者在常规抗菌药物治疗基础上联合手术治疗效果理想,能提高临床疗效,改善患者生活质量,值得推广应用。OBJECTIVE To study clinical treatment of patients with Kluyvera ascorbata caused infections with long time unhealed sinus after thyroid surgeries so as to provide reference for clinical treatments.METHODS Totally 50 cases of patients with K.ascorbata caused infections with long time unhealed sinus after thyroid surgeries from Oct.2014 to Nov.2015 were chosen as study objects.They were divided into control group and experiment group with 25 cases each according to random number method.The control group was treated with routine therapy,while the experiment group was treated with surgery based on routine therapy.The clinical effects of the two groups were compared.RESULTS The overall effect rate of the experiment group was 92.0%,which was significantly higher than that of the control group（72.0%）（P〈0.05）.The serum IL-5and IL-8levels were not significantly different before the treatments.After treatments,serum interleukin-5（IL-5）and serum interleukin-8（IL-8）levels of the experiment group were significantly lower than those of the control group（P〈0.05）.The complication rate was 8.0% in the experiment group,which was significantly lower than that of the control group（36.0%）（P〈0.05）.CONCLUSION Routine therapy combines with surgeries can effectively cure patients with K.ascorbatacaused infections with long time unhealed sinus after thyroid surgeries.It can improve clinical effect as well as improve patients＇ life quality,hence need to be promoted widely.

关 键 词：甲状腺术 切口感染 抗坏血酸克吕沃尔菌 窦道经久不愈 治疗效果 

分 类 号：R378[医药卫生—病原生物学]