高危型HPV亚临床感染干预治疗的临床研究  

Clinical study on the treatment of high risk HPV infection

作　　者：俞晶[1] 杨宏英[1] 张丽娟[1] 张红平[1] 刘莹[1] 

机构地区：[1]昆明医学院第三附属医院妇瘤科,云南昆明650118

出　　处：《中华医院感染学杂志》2016年第13期3069-3071,共3页Chinese Journal of Nosocomiology

基　　金：云南省卫生科技基金资助项目(2012WS0043)

摘　　要：目的探讨不同治疗方案对高危型人乳头瘤病毒(HPV)亚临床感染的治疗效果,为HPV感染的临床治疗提供参考依据。方法选取2012年11月-2015年2月在医院妇科就诊的高危型HPV亚临床感染患者146例,依据随机数表法分为A组、B组、C组,分别为43、56、47例,分别进行保妇康栓治疗、宫颈电灼术、保妇康栓+宫颈电灼术联合治疗,所有患者均于治疗后3、6个月进行复查,观察并记录阴道流液、阴道出血、RLU/CO比值改善情况、HPV、P16阳性率及并发症。结果 A组、B组、C组患者的阴道流液量、阴道流液时间、阴道出血量、阴道出血时间及治疗后3、6个月HPV、P16阳性率均依次降低(P<0.05),RLU/CO比值总改善率分别为67.44%、71.43%、82.98%。结论保妇康栓联合宫颈电灼术治疗高危型HPV亚临床感染成效显著,能够有效抑制HPV感染进一步扩散,降低宫颈癌发生风险。OBJECTIVE To investigate the therapeutic effects of different schemes on the clinical infection of high risk human papillomavirus（HPV）,so as to provide reference for clinical treatment of HPV.METHODS A total of146 cases of patients with high risk subclinical HPV infection in department of gynecology of our hospital from Nov.2012 to Feb.2015 were selected,and divided into group A（43cases）,group B（56cases）,and group C（47cases）according to a random number table.Baofukang suppository treatment,cervical fulguration,and Baofukang suppository combined with cervical fulguration treatment were used for the tree groups,respectively.Three months and six months after treatment,the vaginal fluid,vaginal bleeding,RLU/CO ratio improvement situation,HPV,P16 positive rate and complications were observed and recorded.RESULTS The vaginal fluid amount and time,the vaginal bleeding amount and time,and the HPV and P16 positive rates of group A,group B and group C gradually decreased after 3months and 6months of treatment（P〈0.05）.The RLU/CO ratio improvement rates were 67.44%,71.43%,and 82.98%,respectively.CONCLUSION Baofukang suppository combined with cervical fulguration for the treatment of high risk type HPV subclinical infection have significant effects,can effectively inhibit HPV further spread of infection,and reduce the risk of cervical cancer.

关 键 词：高危型HPV 保妇康栓 宫颈电灼术 

分 类 号：R373[医药卫生—病原生物学]