宫内感染与早产儿脑损伤的关系研究  

Relationship of intrauterine infection and preterm children brain damage with head CT

作　　者：刘玉凤[1] 蔡江云[1] 史春[1] 郑肖瑾 张莉[1] 

机构地区：[1]海口市妇幼保健院新生儿科,海南海口570203

出　　处：《中华医院感染学杂志》2016年第13期3109-3111,共3页Chinese Journal of Nosocomiology

基　　金：海南省卫计委医药卫生科研基金项目资助(琼卫14A210212)

摘　　要：目的分析宫内感染与早产儿脑损伤相关性,为早期诊断治疗提供参考。方法选取产科2015年1月-12月分娩早产儿170例为研究对象,对早产儿孕母检测绒毛膜羊膜炎,判断是否存在宫内感染。早产儿行头颅CT检查确定是否存在脑损伤,分为脑损伤组52例和非脑损伤组118例,采用酶联免疫吸附法测定脐带血各个指标,并检测新生儿出生后C-反应蛋白含量,比较各组生化指标差异。结果早产儿脑损伤组患儿孕母宫内感染率(61.5%)显著高于非脑损伤组(30.5%)(P<0.05),出生1天新生儿脑损伤患者CRP(1.72±6.73)mmol/L显著高于非脑损伤组(0.71±0.24)mmol/L(P<0.05),两组新生儿白细胞计数无明显差异;脑损伤组患儿IL-1β(6.52±2.39)ρ·μg·L^(-1)、IL-6(7.96±4.29)ρ·μg·L^(-1)、TNF-α水平(5.46±1.28)ρ·μg·L^(-1)显著高于非脑损伤组IL-1β(1.52±1.28)ρ·μg·L^(-1)、IL-6(1.62±0.27)ρ·μg·L^(-1)、TNF-α水平(3.26±0.74)ρ·μg·L^(-1)(P<0.05),脑损伤组患儿IL-10水平(1.20±0.26)ρ·μg·L^(-1)显著高于非脑损伤组患儿(1.59±0.28)ρ·μg·L^(-1)(P<0.05)。结论宫内感染早产儿更加容易出现脑损伤,母体怀孕期间需要定期产检,避免宫内感染出现。OBJECTIVE To analyze the relationship of intrauterine infection and preterm children brain damage with head CT,so as to provide reference for clinical diagnosis and treatment.METHODS A total of 170 premature babies in department of obstetrics in our hospital from Jan.2014 to Feb.2015 were selected,and the maternal chorioamnionitis were detected to determine the presence of intrauterine infection.Preterm children were divided into brain injury group（52cases）and the non-brain injury group（118cases）.Various indicators of cord blood were detected by enzyme-linked immunosorbent assay,neonatal CRP were also detected,and the differences of biochemical indexes were compared.RESULTS The maternal intrauterine infection rate of perinatal brain injury group（61.5%）was significantly higher than that of non-brain injury group（30.5%）（P〈0.05）.The CRP level of one-day old babies with neonatal brain injury（1.72±6.73）mmol/L was significantly higher than that of nonbrain injury group（0.71±0.24）mmol/L（P〈0.05）,and the white blood cell count of two groups of newborn had no significant difference（P〉0.05）.The IL-1β（6.52±2.39）ρ·μg·L-1,IL-6（7.96±4.29）ρ·μg·L-1,and TNF-α（5.46±1.28）ρ·μg·L-1levels of brain injury group were significantly higher than those of non-brain injury group,which were（1.52±1.28）ρ·μg·L-1,（1.62±0.27）ρ·μg·L-1,and（3.26±0.74）ρ·μg·L-1（P〈0.05）.The IL-10 level of brain injury group（1.20±0.26）ρ·μg·L-1was significantly higher than that of non-brain injury group（1.59±0.28）ρ·μg·L-1（P〈0.05）.CONCLUSION Intrauterine infection in preterm children are more prone to brain damage,so the mothers need to do regular check-ups during pregnancy to avoid the emergence of intrauterine infection.

关 键 词：宫内感染 早产儿脑损伤 CRP TNF-Α 

分 类 号：R722[医药卫生—儿科]