晚期恶性肿瘤血瘀证与凝血功能及血栓弹力图指标的相关性  

Correlation between Syndrome of Blood Stasis of Late Cancer and Coagulation Function and the Indexes of Thrombelastogram

作　　者：王珂[1] 薛冬[1] 孙红[1] 许轶琛[1] 李元青[1] 陈衍智[1] 李占东[1] 何婷婷[1] 张伟[1] 李萍萍[1] 

机构地区：[1]北京大学肿瘤医院,北京市海淀区阜城路52号100142

出　　处：《中医杂志》2016年第14期1218-1221,共4页Journal of Traditional Chinese Medicine

基　　金：恶性肿瘤发病机制及转化研究教育部重点实验室

摘　　要：目的探讨晚期恶性肿瘤患者血瘀证与静脉血栓形成的关系。方法将70例晚期恶性肿瘤患者按照中医证候诊断标准分为血瘀证组36例、非血瘀证组34例,检测两组患者凝血功能指标(纤维蛋白原,D-二聚体)和血栓弹力图指标(凝血反应时间,凝固角,最大振幅,凝血指数),并分析以上指标与血瘀证的相关性。结果血瘀证组凝固角、纤维蛋白原、D-二聚体水平较非血瘀证组显著升高(P<0.05)。最大振幅、纤维蛋白原、D-二聚体与血瘀证具有明显相关关系(P<0.05),3项指标对证型影响力的排序为:D-二聚体>纤维蛋白原>最大振幅。结论晚期恶性肿瘤患者血瘀证的发生与静脉血栓形成具有相关性,体现在最大振幅、纤维蛋白原、D-二聚体水平升高时血瘀证发生的概率也升高。Objective To explore the relationship between syndrome of blood stasis of patients with late cancer and venous thrombosis. Methods Seventy patients with late cancer were divided into the blood stasis syndrome group（ 36 cases） and the non blood stasis syndrome group（ 34 cases） following the diagnostic criteria of Chinese medicine syndrome. Coagulation function indexes（ fibrinogen and D-dimer） and the indexes of thrombelastogram（ coagulation reaction time,solidification angle,maximum amplitude,and clotting index） of patients in both groups were detected. The correlation between those indexes and blood stasis syndrome were analyzed. Results Compared with those in the non blood stasis syndrome group,solidification angle,fibrinogen and D-dimer in the blood stasis syndrome group increased（ P 〈 0. 05）. There was obvious correlation between maximum amplitude,fibrinogen,as well as D-dimer and blood stasis syndrome（ P 〈 0. 05）. The impact of the 3 indexes on syndrome type was ranked as D-dimer 〉 fibrinogen 〉 maximum amplitude. Conclusion There might be correlation between blood stasis syndrome in patients with late cancer and venous thrombosis. When maximum amplitude,fibrinogen and D-dimer increased,the occurrence probability of blood stasis syndrome increased.

关 键 词：恶性肿瘤 静脉血栓形成 血瘀证 凝血功能 血栓弹力图 

分 类 号：R273[医药卫生—中西医结合]