黄苞南星中的葡萄糖脑苷脂  

Cerebrosides isolated from Arisaema flavum

作　　者：梁天宇[1] 丁克毅[1] 王晓玲[1] 何达海[1] 

机构地区：[1]西南民族大学药学院,四川成都610041

出　　处：《中国中药杂志》2016年第13期2466-2472,共7页China Journal of Chinese Materia Medica

基　　金：中央高校基本科研业务费专项基金项目(2014NZYQN16)

摘　　要：采用硅胶、Sephadex LH-20和反相(C-18)柱色谱等方法研究黄苞南星块茎的化学成分。根据理化性质和波谱学数据与已知化合物对照鉴定了17个葡萄糖脑苷脂类化合物,分别是1-O-β-D-glucopyranosyl-(2S,3R,4E,8E)-2-[(2'(R)-acetoxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol(1),2'-O-acetylsoyacerebroside I(2),1-O-(β-D-glucopyranosyl)-(2S,3R,4E,13Z)-2-[(2'R)-2-hydroxytetradecanoylamino]-1,3-dihydroxy-4,13-docosadiene(3),(2S,3R,4E,8E)1-(β-D-glucopyranosyl)-3-hydroxy-2-[(R)-2'-hydroxyhexadecanoyl]amino-9-methyl-4,8-heptadecadiene(4),(2S,3R,4E,8E)1-(β-D-glucopyranosyl)-3-hydroxy-2-[(R)-2'-hydroxyhexadecanoyl]amino-9-methyl-4,8-octadecadiene(5),(2S,3R,4E,8E)1-(β-D-glucopyranosyl)-3-hydroxy-2-[(R)-2'-hydroxypalmitoyl]amino-9-methyl-4,8-octadecadiene(6),(2S,3R,4E,8E)1-(β-D-glucopyranosyl)-3-hydroxy-2-[(R)-2'-hydroxyoctadecanoyl]amino-9-methyl-4,8-octadecadiene(7),1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(R)-2'-hydroxytetradecanoylamino]-4,8-octadecadiene-1,3-diol(8),1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(R)-2'-hydroxypentadecanoylamino]-4,8-octadecadiene-1,3-diol(9),1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(R)-2'-hydroxyhexadecanoylamino]-4,8-octadecadiene-1,3-diol(10),1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8Z)-2-[(R)-2'-hydroxyhexadecanoylamino]-4,8-octadecadiene-1,3-diol(11),1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(R)-2'-hydroxyoctadecanoylamino]-1,3-hydroxy-4,8-octadecadiene(12),1-O-(β-D-glucopyranosyl)-(2S,3R,4E)-2-[(R)-2'-hydroxytetracosanoylamino]-1,3-hydroxy-4-hexadecane(13),1-O-(β-D-glucopyranosyl)-(2S,3R,4R,8Z)-2N-[(2'R)-2'-hydroxytetracosanoyl]-8-(Z)-octadecene-1,3,4-triol(14),1-O-(β-D-glucopyranosyl)-(2S,3S,4E,8E)-2N-[(2'R)-2'-hydroxyhexadecanoyl]-4-(E),8-(Z)-octadecadiene-1,3-diol(15),typhoniside A(16),1-O-β-D-glucopyranosyl-(2S,3R,8E)-2-[(2'R)-2-hydroxypalmitoylamino]-8-octadecene-1,3-diol(17)。其中化合物1和2为首次从该植物中分离,其余化合物则均为首次从该属植物中分离得到。Silica gel,Sephadex LH-20,and reverse phase（ C-18） column chromatography were used for the research of chemical constituents occurred in Arisaema flavum（ Forsk.） Schott. The structures were elucidated by comparison physico-chemical properties and NMR spectroscopic data with those of known compounds. Seventeen cerebrosides were identified as 1-O-β-D-glucopyranosyl-（ 2S,3R,4E,8E）-2-[（ 2＇（ R）-acetoxyoctadecanoyl） amido]-4,8-octadecadiene-1,3-diol（ 1）,2＇-O-acetylsoyacerebroside I（ 2）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4E,13Z）-2-[（ 2＇R）-2-hydroxytetradecanoylamino]-1,3-dihydroxy-4,13-docosadiene（ 3）,（ 2S,3R,4E,8E） 1-（ β-D-glucopyranosyl）-3-hydroxy-2-[（ R）-2＇-hydroxyhexadecanoyl]amino-9-methyl-4,8-heptadecadiene（ 4）,（ 2S,3R,4E,8E） 1-（ β-D-glucopyranosyl）-3-hydroxy-2-[（ R）-2＇-hydroxyhexadecanoyl]amino-9-methyl-4,8-octadecadiene（ 5）,（ 2S,3R,4E,8E） 1-（ β-D-glucopyranosyl）-3-hydroxy-2-[（ R）-2＇-hydroxypalmitoyl]amino-9-methyl-4,8-octadecadiene（ 6）,（ 2S,3R,4E,8E） 1-（ β-D-glucopyranosyl）-3-hydroxy-2-[（ R）-2＇-hydroxyoctadecanoyl]amino-9-methyl-4,8-octadecadiene（ 7）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4E,8E）-2-[（ R）-2＇-hydroxytetradecanoylamino]-4,8-octadecadiene-1,3-diol（ 8）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4E,8E）-2-[（ R）-2＇-hydroxypentadecanoylamino]-4,8-octadecadiene-1,3-diol（ 9）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4E,8E）-2-[（ R）-2＇-hydroxyhexadecanoylamino]-4,8-octadecadiene-1,3-diol（ 10）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4E,8Z）-2-[（ R）-2＇-hydroxyhexadecanoylamino]-4,8-octadecadiene-1,3-diol（ 11）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4E,8E）-2-[（ R）-2＇-hydroxyoctadecanoylamino]-1,3-hydroxy-4,8-octadecadiene（ 12）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4E）-2-[（ R）-2＇-hydroxytetracosanoylamino]-1,3-hydroxy-4-hexadecane（ 13）,1-O-（ β-D-glucopyranosyl）-（ 2S,3R,4R,8Z）-2N-[（ 2＇R）-2＇-hydroxyt

关 键 词：天南星属 黄苞南星 葡萄糖脑苷脂 

分 类 号：R284[医药卫生—中药学]