功能性氧化石墨烯-β-环糊精/阿司匹林复合物的制备和质量评价及其抗凝血性  

Preparation,quality evaluation and anticoagulant properties of functional graphene oxied-β-cyclodextrin/aspirin compound

作　　者：申玉坤[1,2] 石春花[1] 申玉璞[1] 张龙娇[2] 潘一峰[2] 周晋阳[1] 

机构地区：[1]长治医学院,山西长治046000 [2]中南大学湘雅医学院卫生部纳米生物技术重点实验室,湖南长沙410008

出　　处：《中国医院药学杂志》2016年第13期1047-1050,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家863计划资助项目(编号:2007AA021809)

摘　　要：目的:合成新型的功能性氧化石墨烯-β-环糊精/阿司匹林(GO-DEX-β-CD/ASA)复合物,并对其进行质量评价和抗凝血性研究。方法:利用电子扫描显微镜(SEM)和X-线衍射仪(XRD)对其形貌进行表征;对生成物的包封率、回收率以及精密度进行评价,以离心法测定GO-DEX-β-CD/ASA复合物的包封率;通过溶血试验和复钙试验评价其血液相容性。结果:GODEX-β-CD/ASA复合物的平均回收率(n=3)为(100.3±0.32)%,包封率(n=5)为(76.08±1.06)%,溶血率低于5%,符合生物医学材料的标准。结论:GO-DEX-β-CD/ASA复合物制备工艺可行,质量控制方法简便可靠,具有良好的血液相容性。OBJECTIVE To synthesize new type GO-DEX-β-CD/ASA compound,evaluate qualities and anticoagulant properties.METHODS Microstructure of graphene oxide was characterized by scanning electron microscopy（SEM）and X-ray diffraction（XRD）.Recovery,precision and entrapment efficiency of GO-DEX-β-CD/ASA compound were studied,and GODEX-β-CD/ASA compound entrapment efficiency was determined by centrifugation.Blood compatibility of GO-DEX-β-CD/ASA compound was evaluated by hemolysis test and plasma recalcification time test.RESULTS Average recovery（n=3）of GO-DEX-β-CD/ASA compound was（100.3±0.32）%,with an entrapment efficiency（n=5）of（76.08±1.06）%.Hemolysis rate of GO-DEX-β-CD/ASA compound passed relevant international standard.CONCLUSION Preparation technique of GODEX-β-CD/ASA compound is feasible,quality control method is convenient and reliable,and blood compatibility is good.

关 键 词：阿司匹林 氧化石墨烯 功能性氧化石墨烯-β-环糊精药物载体 功能性氧化石墨烯-β-环糊精/阿司匹林复合物 高效液相色谱法 

分 类 号：R318.08[医药卫生—生物医学工程] Q819[医药卫生—基础医学]