蓬莱葛中一个新的单萜吲哚生物碱  

A New Monoterpenoid Indole Alkaloid from Gardneria multiflora Makino

作　　者：杨万霞[1,2] 黄滔[2] 张建新[2] 刘建华[2] 郝小江[2] 张援虎[2] 

机构地区：[1]贵州大学药学院,贵阳550025 [2]贵州省中国科学院天然产物化学重点实验室,贵阳550002

出　　处：《中国药学杂志》2016年第13期1113-1115,共3页Chinese Pharmaceutical Journal

基　　金：科技部973计划前期研究专项资助项目(2012CB722601);贵州省中药现代化科技产业研究开发专项资助项目(黔科合SY字[2014]3081-1)

摘　　要：目的研究蓬莱葛(Gardneria multiflora Makino)中的单萜吲哚生物碱类成分。方法蓬莱葛全株用体积分数95%乙醇溶液加热回流提取,减压回收乙醇,浓缩液加水稀释后经石油醚、三氯甲烷萃取,得总生物碱。总生物碱利用正相硅胶、反相Rp-18、Sephadex LH-20等柱色谱方法分离纯化,通过光谱数据进行结构鉴定。结果从蓬莱葛中分离得到1个单萜吲哚型生物碱。结论从蓬莱葛中分离得到1个单萜吲哚型生物碱为一新的化合物。OBJECTIVE To study the monoterpenoid indole alkaloids in Gardneria multifiora Makino. METHODS The dried plants of G. multiflora Makino were extracted with 95% ethanol. After removal of solvent, the residue was diluted with water, then extracted with petroleum ether and chloroform to obtain crude alkaloids. Column chromatograghy on silica gel, Rp-18, and Sephadex LH - 20 were applied for the isolation and purification of crude alkaloids. The structure was elucidated based on detailed spectroscopic evidence. RESULTS One monoterpenoid indole alkaloid was isolated from this plant. CONCLUSION Compound gardmuhimine A （1） is a new compound.

关 键 词：单萜吲哚型生物碱 马钱科 蓬莱葛 

分 类 号：R284[医药卫生—中药学]