劲男春颗粒对老龄大鼠阴茎海绵体组织氧化应激损伤的保护作用  

Protective Effects of Jinnanchun Granules(劲男春颗粒) on Oxidative Stress in Cavernous Tissue of Aged Rats

作　　者：陆海旺[1] 林思伟[1] 王杰[1] 王权胜[1] 王德胜[1] 宾彬[1] 

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023

出　　处：《中医药导报》2016年第14期24-26,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广西中医药大学第一附属医院青年科学基金(GZYQJ2014022)

摘　　要：目的:观察中药劲男春颗粒对老龄大鼠阴茎海绵体组织氧化应激损伤的保护作用,为临床推广应用提供理论依据。方法:将45只雄性老龄SD大鼠随机分为劲男春颗粒组、疏肝益阳胶囊组、空白组,每组15只。各组分别给予0.9%氯化钠注射液、疏肝益阳胶囊[1 g/(kg·d)]及劲男春颗粒[8 g/(kg·d)]。给药4周后检测各组大鼠阴茎海绵体组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、一氧化氮合酶(NOS)的含量。结果:劲男春颗粒组大鼠阴茎海绵体的SOD活性显著高于空白组(P<0.01),MDA含量低于空白组(P<0.05),NO含量和NOS活性高于空白组(P<0.05);疏肝益阳胶囊组大鼠阴茎海绵体的NO含量及NOS活性显著高于空白组(P<0.01),MDA含量低于空白组(P<0.05),SOD活性高于空白组(P<0.05);劲男春颗粒组与疏肝益阳胶囊组的SOD、MDA、NO及NOS浓度比较,差异均无统计学意义(P>0.05)。结论:劲男春颗粒对老龄大鼠阴茎海绵体组织氧化应激损伤具有保护作用,通过拮抗阴茎海绵体的氧化应激损伤可能是劲男春颗粒治疗老年性勃起功能障碍的作用机制之一。Objective： To explore the effect of Jinuanehuu Granules （劲男春颗粒 JNCG） on oxidative stress in cavernous tissue of aged rats. Methods： The 45 SD rats were randomly divided into JNCG group, Shugan Yiyang Capsule （疏肝益阳胶囊, SGYYC） group and blank group, 15 rats in eaeh group. The hlank group was given normal saline daily, JNCG group was astrieed JNCG [8 g/（kg·d）] daily and SGYYC group received SGYYC [1 g/（kg·d）l daily. After four weeks, the levels of Mahmdiahlehyde （MDA） and nitrogen monoxide （NO）, activities of superoxide dismutase （SOD） and Nitrieoxidesynthase （NOS） in eavernons tissue were deleeled. Results： Compared with that of the blank group, the activities of SOD inereased remarkably in eavernous lissue of both in JNCG aged rats （P〈0.01） and SGYYG （P〈0.05）： the activities of NOS inereased signifieantly in cavernous tissue of both in JNCG aged rats （P〈0.05） and SGYYG （P〈0.01）; the level of MDA deereased hoth in JNCG （P〈0.05） and SGYYG（P〈0.05）; the level of NO increased signifieantly both in JNCG （P〈0.05） and SGYYG （P〈0.01）;all Ihe measurement index showed no differenee between JNCG and SGYYG （P〉0.05）. Conclusions： JNCG might attenuate oxidative stress, which may he one of the mechanisms of JNCG healing aged-related erectile dysfunction.

关 键 词：劲男春颗粒 老年性勃起功能障碍 氧化应激 抗氧化 大鼠 

分 类 号：R285.5[医药卫生—中药学]