Two paths for stabilization of ERG in prostate carcinogenesis： TMPRSS2-ERG fusions and speckle-type pox virus and zinc finger protein mutations  

作　　者：Laura E Pascal Zhou Wang 

机构地区：[1]Department of Urology [2]University of Pittsburgh Cancer Institute [3]Department of Pharmacology and Chemical Biology [4]Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.

出　　处：《Asian Journal of Andrology》2016年第4期594-595,共2页亚洲男性学杂志（英文版）

摘　　要：Speckle-type POZ （pox virus and zinc finger protein） protein （SPOP） is anE3 ubiquitin ligase adaptor protein that specifically promotes the ubiquitination and proteasome degradation of proteins. SPOP mutations are frequent in prostate cancer, and in a previous study, An et al. demonstrated that SPOP induced the degradation of the androgen receptor （AR） suggesting that SPOP is important in maintaining prostate homeostasis. In this current highlighted report, An and colleagues showed that ERG, which has been implicated as an oncoprotein in prostate cancer.Speckle-type POZ （pox virus and zinc finger protein） protein （SPOP） is anE3 ubiquitin ligase adaptor protein that specifically promotes the ubiquitination and proteasome degradation of proteins. SPOP mutations are frequent in prostate cancer, and in a previous study, An et al. demonstrated that SPOP induced the degradation of the androgen receptor （AR） suggesting that SPOP is important in maintaining prostate homeostasis. In this current highlighted report, An and colleagues showed that ERG, which has been implicated as an oncoprotein in prostate cancer.

分 类 号：Q513.1[生物学—生物化学] Q78