载脂蛋白CⅠ和维生素E结合蛋白与肺结核脂质代谢的相关性  

Relationship of apolipoprotein C-I and vitamin E-binding protein with lipid metabolism in patients with pulmonary tuberculosis

作　　者：尉理梁 王建华 毕德青[2] 李梦婷[2] 徐方艳 张秀军 施力颖 江婷婷[5] 

机构地区：[1]浙江省绍兴市立医院呼吸科,312000 [2]杭州市萧山区中医院中医内科,311201 [3]杭州市萧山区中医院检验科,311201 [4]浙江医院医学检验科,杭州310013 [5]浙江大学医学院细胞生物学研究所,杭州310058

出　　处：《国际流行病学传染病学杂志》2016年第3期169-172,共4页International Journal of Epidemiology and Infectious Disease

基　　金：国家重点基础研究发展计划（973计划）（2014CB543002）;“十二五”国家科技重大专项（2012ZX10005001-006）;国家自然科学基金（81273882）;浙江省医药卫生科技计划项目（2013KYA209）

摘　　要：目的：探讨载脂蛋白CⅠ（ApoC1）和维生素E结合蛋白（AFM）与肺结核患者脂质代谢的相关性。方法采用ELISA法检测ApoC1、AFM在31例肺结核患者（肺结核组）和26名正常人（正常对照组）血清中的含量，两组均空腹抽血检测总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A1、载脂蛋白B、脂蛋白A和视黄醇结合蛋白等指标，并分析肺结核组血清差异蛋白质与临床检测指标的相关性。结果肺结核组ApoC1含量为（34.60±4.60）μg/mL，显著低于对照组的（38.43±5.12）μg/mL （t=2.703，P〈0.01）；肺结核组AFM含量为（15.69±6.79）μg/mL，高于对照组的（11.95±6.36）μg/mL（t=2.054，P〈0.05），且AFM 与患者的甘油三酯含量存在负相关性（rs=-0.371，P〈0.05）；ApoC1与所有临床指标均无相关性。结论 ApoC1和AFM可能参与了肺结核患者的脂质代谢。Objective To explore the relevance between lipid metabolism and the proteins of apolipoprotein C-Ⅰ （ApoC1） and vitamin E-binding protein （AFM） in TB patients. Methods The concentration of ApoC1 and AFM in 31 TB cases and 26 healthy controls were detected by ELISA. Both groups received fasting hemospasia, and the clinical indexes including total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, ApoA1, ApoB, lipoprotein B and retinol binding protein （RBP） were detected. The correlations of the proteins with clinical indexes in TB patients were also analyzed. Results The concentration of ApoC1 in TB cases was lower than that in healthy controls [（34.60±4.60）μg/mL vs（38.43±5.12）μg/mL, t=2.703, P〈0.01]. The concentration of AFM in TB cases was higher than that in healthy controls [（15.69±6.79） μg/mL vs （11.95±6.36）μg/mL, t=2.054, P〈0.05]. The concentration of AFM was negatively correlated with the serum level of TG （rs=-0.371, P〈0.05）. None of clinical indexes had correlation with APOC1. Conclusions ApoC1 and AFM may be associated with liqid metabolism in TB patients.

关 键 词：结核 肺 蛋白质 载脂蛋白C I 维生素E结合蛋白 

分 类 号：R521[医药卫生—内科学]