HIV-1病毒储存库的清除策略研究进展  

Advances on the elimination of HIV-1 reservoirs

作　　者：温春燕[1] 冯理智 胡凤玉[1] 蔡卫平[1] 

机构地区：[1]广州市第八人民医院感染科,510060

出　　处：《国际流行病学传染病学杂志》2016年第3期203-206,共4页International Journal of Epidemiology and Infectious Disease

摘　　要：HAART可有效控制HIV复制，使HIV/AIDS患者生存期延长和死亡率降低，但由于HIV-1病毒储存库的存在，无法根除HIV。此文将介绍HIV-1病毒库的定义、病毒库检测方法及可能的清除机制，包括IFN联合HAART治疗、重新激活静息的HIV感染细胞、采用免疫疗法杀灭潜伏感染的细胞、编辑基因诱导目标细胞产生抗性等，为实现治愈HIV的目标提供参考依据。HAART can successfully reduce HIV replication, so as to prolong survival period and reduce mortality. However, HAART cannot cure HIV because of the long-living HIV-1 reservoirs. In this article, the definition of HIV reservoirs and reservoir detection methods are introduced, and the possible elimination methods including IFN combined HAART treatment, “shock and kill” treatment, kill of persisting HIV infected cells by immunotherapy and gene editioring to induce antibody in target cells are summarized. These elimination strategies can provide a reference basis for achieving the goal for curing HIV.

关 键 词：HIV-1 病毒储存库 CD4^+T细胞 基因编辑 

分 类 号：R512.91[医药卫生—内科学]