非肌肉肌球蛋白ⅡA的相互作用蛋白研究进展  

Advances in Study on Proteins Interacted with the Non-muscle Myosin ⅡA

作　　者：唐友梅[1] 曹国胜[1] 余秀[1] 张媛媛[1] 寇俊萍[1] 

机构地区：[1]江苏省中药评价与转化重点实验室中国药科大学中药复方研究室,江苏南京211198

出　　处：《现代生物医学进展》2016年第21期4159-4164,共6页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81274131)

摘　　要：非肌肉肌球蛋白ⅡA(NMⅡA)是肌球蛋白超家族的成员之一,其生物学功能已引起国内外学者的广泛重视。研究发现,NMⅡA可作为分子马达为细胞内分子运动提供动力;还可通过与其他蛋白质发生相互作用而参与细胞黏附与迁移、细胞吞噬、胞质分裂等多种生理病理活动。本文综述了与NMⅡA存在相互作用的蛋白质及其产生的生物学效应,以期为全面了解NMⅡA的生理病理功能,深入探讨肿瘤等重大疾病的发病机制及新药研发提供一定线索和依据。Non-muscle myosin Ⅱ A（NM Ⅱ A） belongs to the conventional myosin Ⅱ superfamily. Recently, NM Ⅱ A has aroused more and more attention from domestic and overseas experts. NM Ⅱ A is a motor protein that provides force for intracellular movements. It also regulates a wide range of cellular functions, such as migration, adhesion, phagocytosis and cytokinesis, which requires various protein-protein interactions. The latest abroad research of proteins interacted with the non-muscle myosin ⅡA and its biologic effects have been reviewed in this review, so as to provide related information for the physiological and pathological functions of NM ⅡA,pathogenesis of the related serious diseases and innovation of new drugs.

关 键 词：非肌肉肌球蛋白ⅡA 蛋白质相互作用 生物学功能 信号转导 

分 类 号：Q591[生物学—生物化学] Q593