2型糖尿病肾病患者血清胱抑素C与传统肾功能测定的临床价值  

Clinical value of serum cystatin C and conventional renal function detection in type 2 diabetic nephropathy patients

作　　者：徐福平[1] 张栋武 

机构地区：[1]佛山市高明区人民医院,528500

出　　处：《中国实用医药》2016年第14期8-9,共2页China Practical Medicine

摘　　要：目的探讨血清胱抑素C(Cys C)与传统肾功能检测指标在2型糖尿病肾病监测中的临床价值。方法 150例2型糖尿病肾病患者,其中Ⅰ、Ⅱ、Ⅲ期各50例,采用全自动生化学/酶法测定各期患者血清Cys C、尿素(Ur)、肌酐(Scr)含量,并进行比较。结果 2型糖尿病肾病患者Ⅰ期与Ⅱ期、Ⅱ期与Ⅲ期、Ⅰ期与Ⅲ期Cys C含量比较差异均有统计学意义(P<0.05);2型糖尿病肾病患者Ⅰ期与Ⅱ期、Ⅱ期与Ⅲ期Ur、Scr含量比较差异均无统计学意义(P>0.05);Ⅰ期与Ⅲ期患者Ur、Scr含量比较差异均有统计学意义(P<0.05)。结论 2型糖尿病肾病患者存在不同程度的肾功能改变,血清Cys C测定较传统Ur、Scr监测更能反映患者早期肾损伤。ObjectiveTo investigate clinical value of serum cystatin C （CysC） and conventional renal function detection in monitoring of type 2 diabetic nephropathy patients.MethodsThere were 150 patients with type 2 diabetic nephropathy, as 50 cases in each stage of Ⅰ, Ⅱ and Ⅲ. Automatic biochemistry/enzyme was applied to detect serum CysC, urea （Ur） and creatinine （Scr） contents for comparison.ResultsThe differences of CysC contents between stage Ⅰ and Ⅱ, stage Ⅱ and Ⅲ, stage Ⅰ and Ⅲ of type 2 diabetic nephropathy patients all had statistical significance （P〈0.05）. There was no statistically significant difference of Ur and Scr contents between stage Ⅰ and Ⅱ, stage Ⅱ and Ⅲ patients （P〉0.05）, while the difference of Ur and Scr contents between stageⅠ and Ⅲ had statistical significance （P〈0.05）.ConclusionDue to different renal function changes in type 2 diabetic nephropathy patients, detection of serum CysC shows better expression of early renal damage than conventional detection of Ur and Scr.

关 键 词：2型糖尿病 肾病 血清胱抑素C 肾功能 

分 类 号：R587.2[医药卫生—内分泌]