43例HIV/AIDS患者抗病毒治疗情况分析  

Analysis of the Efficacy of Antiretroviral Treatment in 43 Cases of HIV/AIDS Patients

作　　者：白帆[1] 李建辉[1] 汪春付[1] 党便利 刘青[1] 庄严[1] 康文[1] 姚娜[1] 孙永涛[1] 

机构地区：[1]第四军医大学唐都医院传染科,陕西西安710038

出　　处：《现代生物医学进展》2016年第19期3658-3660,共3页Progress in Modern Biomedicine

基　　金：国家"十二五"科技重大专项(2014ZX10001002)

摘　　要：目的:研究来第四军医大学唐都医院传染科就诊的人类免疫缺陷病毒/艾滋病(Human immunodeficiency virus/Acquired immuno deficiency syndrome,HIV/AIDS)患者感染状况及抗病毒治疗效果。方法:采用前瞻性随访研究的方法,收集来我院就诊的HIV/AIDS患者的基本信息,并对其实验室检查结果、治疗方案及后续随访结果进行分析。结果:随访观察的43例HIV/AIDS患者治疗前平均基线CD4+T淋巴细胞计数为(330.74±176.35)cells/μL,CD8+T淋巴细胞计数为(1177.80±321.49)cells/μL,CD4+,CD8+T淋巴细胞比值为0.30±0.19;治疗一年后平均CD4+T淋巴细胞计数为(482.74±217.77)cells/μL,CD8+T淋巴细胞计数为(861.53±282.85)cells/μL,CD4+,CD8+T淋巴细胞比值为0.59±0.28。所有患者治疗一年后血浆HIV-RNA载量均达到检测限以下(<500copies/m L)。结论:规范的抗病毒治疗对于改善HIV/AIDS患者预后至关重要;基线CD4+T淋巴细胞计数越低,抗病毒治疗效果越差。Objective： To investigate the infection status and the effect of antiretroviral treatment（ART） on HIV/AIDS patients in the Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University. Methods： The follow-up study was conducted prospectively. The basic information of HIV/AIDS patients were collected. Laboratory examinations, therapeutic regimens and follow-up information were analyzed. Results： In the investigation of 43 HIV/AIDS patients, the average baseline CD4＋T cell count prior treatment was（330.74±176.35） cells/μL, CD8^＋T cell count was（1177.80±321.49） cells/μL, CD4^＋/CD8^＋ratio was 0.30±0.19. The average CD4^＋T cell count one year after treatment was（482.74 ±217.77） cells/μL, CD8＋T cell count was（861.53 ±282.85） cells/μL,CD4^＋/CD8^＋ratio was 0.59±0.28. After one year of HAART, plasma HIV-RNA load was undetectable in all patients. Conclusion： Standard ART is helpful in improving prognosis of HIV/AIDS patients. The lower the baseline CD4＋T cell counts, the poorer the ART effects.

关 键 词：人类免疫缺陷病毒 艾滋病 CD4+T淋巴细胞 高效抗逆转录病毒治疗 

分 类 号：R512.91[医药卫生—内科学]