TGF-β2和TGFβRⅡ在外阴鳞癌中的表达及意义  

Expression and Clinical Significance of TGF-β2 and TGFβRⅡ in the Vulvar Squamous Cell Carcinoma

作　　者：杨秀华[1] 郭峰[2] 任丽娜[1] 赵毅[1] 武昕[3] 

机构地区：[1]中国医科大学附属第一医院产科,辽宁沈阳110001 [2]中国医科大学附属盛京医院急诊科,辽宁沈阳110001 [3]中国医科大学附属第一医院妇科,辽宁沈阳110001

出　　处：《现代生物医学进展》2016年第19期3751-3754,共4页Progress in Modern Biomedicine

基　　金：辽宁省自然科学基金项目(2014021057)

摘　　要：目的:探讨外阴鳞癌(VSCC)中转化生长因子-β2(TGF-β2)和转化生长因子受体βRⅡ(TGFβRⅡ)蛋白的表达及其临床病理意义。方法:收集30例外阴鳞癌及10例外阴整形时切下的外阴正常皮肤组织。所有组织来自2012年1月至2015年10月在我院妇科行手术治疗的患者。采用免疫组化方法检测TGF-β2及TGFβRⅡ蛋白的表达。结果:外阴鳞癌组织中TGF-β2的阳性表达率显著高于正常外阴组织(90%vs 20%),差异有统计学意义(P<0.05),TGF-β2的表达与肿瘤分化程度、FIGO分期无关(P>0.05),但与淋巴结是否转移显著相关(P<0.05)。外阴鳞癌组织中TGFβRⅡ的阳性表达低于正常外阴组织(13.33%vs 70%),差异有统计学意义(P<0.05),TGFβRⅡ的表达与肿瘤分化程度、FIGO分期和淋巴结是否转移均无显著相关性(P>0.05)。结论:TGF-β2的表达上调与外阴鳞癌的发生及其淋巴结转移有关,可能是VSCC的治疗靶点。TGFβRⅡ的表达下调可能参与了外阴鳞癌的发生。Objective： To investigate the expression and clinical significance of transforming growth factor beta 2（TGF-β2）and transforming growth factor beta receptor 2（TGFβRⅡ） in VSCC. Methods： 30 freshly frozen VSCC samples and 10 cases of normal vulvar squamous epithelium from patients undergoing vulva plastic surgery were collected. All of the tissues were obtained from the Department of Gynaecology in our hospital at the time of surgery from January 2012 to October 2015. The expressions of TGF-β2 and TGFβRⅡ of the specimens were determined by immunohistochemistry method. Results： The expression of TGFβ2 was significantly higher in the VSCC compared with the control tissues（90 % vs 20 %）（P〈0.05）, the TGF-β2 level was not correlated with the tumour differentiation and FIGO stage（P〈0.05）, but was positively correlated with the lymph node metastasis of VSCC（P〈0.05）. The expression level of TGFβRⅡ was significantly lower in the VSCC compared with control tissues（13.33 % vs 70 %）, the TGFβRⅡ level was not correlated with tumour differentiation, FIGO stage and lymph node metastasis（P〉0.05）. Conclusion： The up-regulation of TGF-β2 was found to be associated with the tumourigenesis of VSCC and lymphatic metastasis, TGF-β2 might be a critical therapeutic target in the VSCC.Down-regulation of TGFβRⅡ might be associated with the tumourigenesis of VSCC.

关 键 词：外阴鳞癌 转化生长因子-Β2 转化生长因子受体βRⅡ 

分 类 号：R737.35[医药卫生—肿瘤]